Abstract
Objective: To examine whether overlapping cognitive deficits exist in currently drug-abstinent chronic methamphetamine (MA) abusers and schizophrenia (SZ) patients. BACKGROUND: Both SZ and chronic MA abuse are associated with frontostriatal disruption as well as deficits in cognitive control, such as selective attention. To identify overlapping cognitive profiles, we compared performance of the 2 groups on the Stroop attention task. METHODS: Data were analyzed from 69 MA abusers who had been MA-abstinent for differing periods of time and from 23 SZ patients and 38 non-substance-abusing controls. RESULTS: The MA abusers in early abstinence displayed more Stroop interference than the SZ patients (P=0.004), long-term abstinent MA abusers (P=0.009), and controls (P=0.002). In the MA abusers, the magnitude of Stroop interference correlated positively with longer drug use (P=0.01) and negatively with longer drug abstinence (P=0.04). No correlations were found between psychotic symptoms and task performance. CONCLUSIONS: On this task of attentional selection, only the MA abusers in early stages of abstinence showed performance deficits compared with controls. More research is needed to further elucidate overlapping patterns between MA abuse and SZ.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-193 |
| Number of pages | 7 |
| Journal | Cognitive and Behavioral Neurology |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2011 |
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Keywords
- cognition
- methamphetamine
- schizophrenia
- selective attention
- Stroop
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Psychiatry and Mental health
- Cognitive Neuroscience
Cite this
Overlapping cognitive patterns in schizophrenia and methamphetamine dependence. / Salo, Ruth; Ravizza, Susan; Fassbender, Catherine.
In: Cognitive and Behavioral Neurology, Vol. 24, No. 4, 12.2011, p. 187-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overlapping cognitive patterns in schizophrenia and methamphetamine dependence
AU - Salo, Ruth
AU - Ravizza, Susan
AU - Fassbender, Catherine
PY - 2011/12
Y1 - 2011/12
N2 - Objective: To examine whether overlapping cognitive deficits exist in currently drug-abstinent chronic methamphetamine (MA) abusers and schizophrenia (SZ) patients. BACKGROUND: Both SZ and chronic MA abuse are associated with frontostriatal disruption as well as deficits in cognitive control, such as selective attention. To identify overlapping cognitive profiles, we compared performance of the 2 groups on the Stroop attention task. METHODS: Data were analyzed from 69 MA abusers who had been MA-abstinent for differing periods of time and from 23 SZ patients and 38 non-substance-abusing controls. RESULTS: The MA abusers in early abstinence displayed more Stroop interference than the SZ patients (P=0.004), long-term abstinent MA abusers (P=0.009), and controls (P=0.002). In the MA abusers, the magnitude of Stroop interference correlated positively with longer drug use (P=0.01) and negatively with longer drug abstinence (P=0.04). No correlations were found between psychotic symptoms and task performance. CONCLUSIONS: On this task of attentional selection, only the MA abusers in early stages of abstinence showed performance deficits compared with controls. More research is needed to further elucidate overlapping patterns between MA abuse and SZ.
AB - Objective: To examine whether overlapping cognitive deficits exist in currently drug-abstinent chronic methamphetamine (MA) abusers and schizophrenia (SZ) patients. BACKGROUND: Both SZ and chronic MA abuse are associated with frontostriatal disruption as well as deficits in cognitive control, such as selective attention. To identify overlapping cognitive profiles, we compared performance of the 2 groups on the Stroop attention task. METHODS: Data were analyzed from 69 MA abusers who had been MA-abstinent for differing periods of time and from 23 SZ patients and 38 non-substance-abusing controls. RESULTS: The MA abusers in early abstinence displayed more Stroop interference than the SZ patients (P=0.004), long-term abstinent MA abusers (P=0.009), and controls (P=0.002). In the MA abusers, the magnitude of Stroop interference correlated positively with longer drug use (P=0.01) and negatively with longer drug abstinence (P=0.04). No correlations were found between psychotic symptoms and task performance. CONCLUSIONS: On this task of attentional selection, only the MA abusers in early stages of abstinence showed performance deficits compared with controls. More research is needed to further elucidate overlapping patterns between MA abuse and SZ.
KW - cognition
KW - methamphetamine
KW - schizophrenia
KW - selective attention
KW - Stroop
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UR - http://www.scopus.com/inward/citedby.url?scp=83655164632&partnerID=8YFLogxK
U2 - 10.1097/WNN.0b013e31823fc1d0
DO - 10.1097/WNN.0b013e31823fc1d0
M3 - Article
C2 - 22123586
AN - SCOPUS:83655164632
VL - 24
SP - 187
EP - 193
JO - Cognitive and Behavioral Neurology
JF - Cognitive and Behavioral Neurology
SN - 1543-3633
IS - 4
ER -