Overcoming original (antigenic) sin

David E. Anderson, Maria P. Carlos, Lynn Nguyen, Jose V Torres

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to the development of vaccines against viruses such as human immunodeficiency virus and hepatitis C virus, in which myriad viral variants are present throughout the human population. We have compared the effects of priming the immune system with a single peptide epitope or with a cocktail of related peptides based on the epitope. Our data demonstrate that immunization with multiple peptide variants expands a more broadly reactive and durable T helper cell response than does immunization with a single peptide. This vaccine strategy may circumvent original antigenic sin.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalClinical Immunology
Volume101
Issue number2
DOIs
StatePublished - 2001

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Helper-Inducer T-Lymphocytes
Peptides
Antibody Formation
Epitopes
Immunization
Vaccines
Virus Diseases
Coinfection
Hepacivirus
Immune System
HIV
Viruses
Population

Keywords

  • AIDS
  • HIV
  • Memory
  • Peptide
  • T cell
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Overcoming original (antigenic) sin. / Anderson, David E.; Carlos, Maria P.; Nguyen, Lynn; Torres, Jose V.

In: Clinical Immunology, Vol. 101, No. 2, 2001, p. 152-157.

Research output: Contribution to journalArticle

Anderson, DE, Carlos, MP, Nguyen, L & Torres, JV 2001, 'Overcoming original (antigenic) sin', Clinical Immunology, vol. 101, no. 2, pp. 152-157. https://doi.org/10.1006/clim.2001.5114
Anderson, David E. ; Carlos, Maria P. ; Nguyen, Lynn ; Torres, Jose V. / Overcoming original (antigenic) sin. In: Clinical Immunology. 2001 ; Vol. 101, No. 2. pp. 152-157.
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