Overcoming original (antigenic) sin

David E. Anderson, Maria P. Carlos, Lynn Nguyen, Jose V Torres

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to the development of vaccines against viruses such as human immunodeficiency virus and hepatitis C virus, in which myriad viral variants are present throughout the human population. We have compared the effects of priming the immune system with a single peptide epitope or with a cocktail of related peptides based on the epitope. Our data demonstrate that immunization with multiple peptide variants expands a more broadly reactive and durable T helper cell response than does immunization with a single peptide. This vaccine strategy may circumvent original antigenic sin.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalClinical Immunology
Issue number2
StatePublished - 2001


  • AIDS
  • HIV
  • Memory
  • Peptide
  • T cell
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine


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