Abstract
Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to the development of vaccines against viruses such as human immunodeficiency virus and hepatitis C virus, in which myriad viral variants are present throughout the human population. We have compared the effects of priming the immune system with a single peptide epitope or with a cocktail of related peptides based on the epitope. Our data demonstrate that immunization with multiple peptide variants expands a more broadly reactive and durable T helper cell response than does immunization with a single peptide. This vaccine strategy may circumvent original antigenic sin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 152-157 |
| Number of pages | 6 |
| Journal | Clinical Immunology |
| Volume | 101 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2001 |
Fingerprint
Keywords
- AIDS
- HIV
- Memory
- Peptide
- T cell
- Vaccine
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Overcoming original (antigenic) sin. / Anderson, David E.; Carlos, Maria P.; Nguyen, Lynn; Torres, Jose V.
In: Clinical Immunology, Vol. 101, No. 2, 2001, p. 152-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overcoming original (antigenic) sin
AU - Anderson, David E.
AU - Carlos, Maria P.
AU - Nguyen, Lynn
AU - Torres, Jose V
PY - 2001
Y1 - 2001
N2 - Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to the development of vaccines against viruses such as human immunodeficiency virus and hepatitis C virus, in which myriad viral variants are present throughout the human population. We have compared the effects of priming the immune system with a single peptide epitope or with a cocktail of related peptides based on the epitope. Our data demonstrate that immunization with multiple peptide variants expands a more broadly reactive and durable T helper cell response than does immunization with a single peptide. This vaccine strategy may circumvent original antigenic sin.
AB - Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to the development of vaccines against viruses such as human immunodeficiency virus and hepatitis C virus, in which myriad viral variants are present throughout the human population. We have compared the effects of priming the immune system with a single peptide epitope or with a cocktail of related peptides based on the epitope. Our data demonstrate that immunization with multiple peptide variants expands a more broadly reactive and durable T helper cell response than does immunization with a single peptide. This vaccine strategy may circumvent original antigenic sin.
KW - AIDS
KW - HIV
KW - Memory
KW - Peptide
KW - T cell
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=0035183490&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035183490&partnerID=8YFLogxK
U2 - 10.1006/clim.2001.5114
DO - 10.1006/clim.2001.5114
M3 - Article
C2 - 11683574
AN - SCOPUS:0035183490
VL - 101
SP - 152
EP - 157
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 2
ER -