Ovarian cancer in younger vs older women: A population-based analysis

J. K. Chan, R. Urban, M. K. Cheung, K. Osann, A. Husain, N. N. Teng, D. S. Kapp, J. S. Berek, Gary S Leiserowitz

Research output: Contribution to journalArticle

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Abstract

To compare the clinico-pathologic prognostic factors and survival of younger vs older women diagnosed with epithelial ovarian cancer. Demographic, clinico-pathologic, treatment, and surgery information were obtained from patients with ovarian cancer from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001 and analysed using Kaplan-Meier estimates. Of 28 165 patients, 400 were < 30 years (very young), 11 601 were 30-60 (young), and 16 164 were > 60 (older) years of age. Of the very young, young, and older patients, 261 (65.3), 4664 (40.2%), and 3643 (22.5%) had stage I-II disease, respectively (P <0.001). Across all stages, very young women had a significant survival advantage over the young and older groups with 5-year disease-specific survival estimates at 78.8% vs 58.8 and 35.3%, respectively (P <0.001). This survival difference between the age groups persists even after adjusting for race, stage, grade, and surgical treatment. Reproductive age (16-40 years) women with stage I-II epithelial ovarian cancer who received uterine-sparing procedures had similar survivals compared to those who underwent standard surgery (93.3% vs 91.5%, P = 0.26). Younger women with epithelial ovarian cancer have a survival advantage compared to older patients.

Original languageEnglish (US)
Pages (from-to)1314-1320
Number of pages7
JournalBritish Journal of Cancer
Volume95
Issue number10
DOIs
StatePublished - Nov 20 2006

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Ovarian Neoplasms
Survival
Population
SEER Program
Kaplan-Meier Estimate
Age Groups
Demography
Therapeutics
Ovarian epithelial cancer

Keywords

  • Ovarian cancer
  • Survival
  • Uterine-sparing
  • Young

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chan, J. K., Urban, R., Cheung, M. K., Osann, K., Husain, A., Teng, N. N., ... Leiserowitz, G. S. (2006). Ovarian cancer in younger vs older women: A population-based analysis. British Journal of Cancer, 95(10), 1314-1320. https://doi.org/10.1038/sj.bjc.6603457

Ovarian cancer in younger vs older women : A population-based analysis. / Chan, J. K.; Urban, R.; Cheung, M. K.; Osann, K.; Husain, A.; Teng, N. N.; Kapp, D. S.; Berek, J. S.; Leiserowitz, Gary S.

In: British Journal of Cancer, Vol. 95, No. 10, 20.11.2006, p. 1314-1320.

Research output: Contribution to journalArticle

Chan, JK, Urban, R, Cheung, MK, Osann, K, Husain, A, Teng, NN, Kapp, DS, Berek, JS & Leiserowitz, GS 2006, 'Ovarian cancer in younger vs older women: A population-based analysis', British Journal of Cancer, vol. 95, no. 10, pp. 1314-1320. https://doi.org/10.1038/sj.bjc.6603457
Chan JK, Urban R, Cheung MK, Osann K, Husain A, Teng NN et al. Ovarian cancer in younger vs older women: A population-based analysis. British Journal of Cancer. 2006 Nov 20;95(10):1314-1320. https://doi.org/10.1038/sj.bjc.6603457
Chan, J. K. ; Urban, R. ; Cheung, M. K. ; Osann, K. ; Husain, A. ; Teng, N. N. ; Kapp, D. S. ; Berek, J. S. ; Leiserowitz, Gary S. / Ovarian cancer in younger vs older women : A population-based analysis. In: British Journal of Cancer. 2006 ; Vol. 95, No. 10. pp. 1314-1320.
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