Outside the box signaling: Secreted factors modulate GnRH receptor-mediated gonadotropin regulation

Hanna Pincas, Soon Gang Choi, Qian Wang, Jingjing Jia, Judith L Turgeon, Stuart C. Sealfon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Control of gene expression following activation of membrane receptors results from the regulation of intracellular signaling pathways and transcription factors. Accordingly, research to elucidate the regulatory control circuits and cellular data processing mechanisms focuses on intracellular mechanisms. While autocrine and paracrine signaling are acknowledged in endocrinology, secreted factors are not typically recognized as fundamental components of the pathways connecting cell surface receptors to gene control in the nucleus. Studies of the gonadotrope suggest that extracellular regulatory loops may play a central role in the regulation of gonadotropin gene expression by gonadotropin-releasing hormone (GnRH) receptor activation. We review emerging evidence for this phenomenon, which we refer to as exosignaling, in gonadotropin gene control and in other receptor-mediated signaling systems. We propose that basic signaling circuit modules controlling gene expression can be seamlessly distributed across intracellular and exosignaling components that together orchestrate the precise physiological control of gene expression.

Original languageEnglish (US)
Pages (from-to)56-61
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume385
Issue number1-2
DOIs
StatePublished - Mar 25 2014

Fingerprint

LHRH Receptors
Gonadotropins
Gene expression
Gene Expression
Autocrine Communication
Paracrine Communication
Endocrinology
Gene Expression Regulation
Cell Surface Receptors
Genes
Chemical activation
Transcription Factors
Networks (circuits)
Membranes
Research

Keywords

  • Autocrine
  • Exosignaling
  • GnRH
  • Inhibin α
  • PACAP
  • Prostaglandins

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

Outside the box signaling : Secreted factors modulate GnRH receptor-mediated gonadotropin regulation. / Pincas, Hanna; Choi, Soon Gang; Wang, Qian; Jia, Jingjing; Turgeon, Judith L; Sealfon, Stuart C.

In: Molecular and Cellular Endocrinology, Vol. 385, No. 1-2, 25.03.2014, p. 56-61.

Research output: Contribution to journalArticle

Pincas, Hanna ; Choi, Soon Gang ; Wang, Qian ; Jia, Jingjing ; Turgeon, Judith L ; Sealfon, Stuart C. / Outside the box signaling : Secreted factors modulate GnRH receptor-mediated gonadotropin regulation. In: Molecular and Cellular Endocrinology. 2014 ; Vol. 385, No. 1-2. pp. 56-61.
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