TY - JOUR
T1 - Outdoor air pollution and new-onset airway disease
T2 - An official american thoracic society workshop report
AU - American Thoracic Society Assembly on Environmental, Occupational and Population Health
AU - Thurston, George D.
AU - Balmes, John R.
AU - Garcia, Erika
AU - Gilliland, Frank D.
AU - Rice, Mary B.
AU - Schikowski, Tamara
AU - Van Winkle, Laura S
AU - Annesi-Maesano, Isabella
AU - Burchard, Esteban G.
AU - Carlsten, Christopher
AU - Harkema, Jack R.
AU - Khreis, Haneen
AU - Kleeberger, Steven R.
AU - Kodavanti, Urmila P.
AU - London, Stephanie J.
AU - McConnell, Rob
AU - Peden, Dave B.
AU - Pinkerton, Kent E.
AU - Reibman, Joan
AU - White, Carl W.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Although it is well accepted that air pollution exposure exacerbates preexisting airway disease, it has not been firmly established that long-term pollution exposure increases the risk of new-onset asthma or chronic obstruction pulmonary disease (COPD). This Workshop brought together experts on mechanistic, epidemiological, and clinical aspects of airway disease to review current knowledge regarding whether air pollution is a causal factor in the development of asthma and/or COPD. Speakers presented recent evidence in their respective areas of expertise related to air pollution and new airway disease incidence, followed by interactive discussions. A writing committee summarized their collective findings. The Epidemiology Group found that long-term exposure to air pollution, especially metrics of traffic-related air pollution such as nitrogen dioxide and black carbon, is associated with onset of childhood asthma. However, the evidence for a causal role in adultonset asthma or COPD remains insufficient. The Mechanistic Group concluded that air pollution exposure can cause airway remodeling, which can lead to asthma or COPD, as well as asthma-like phenotypes that worsen with long-term exposure to air pollution, especially fine particulate matter and ozone. The Clinical Group concluded that air pollution is a plausible contributor to the onset of both asthma and COPD. Available evidence indicates that long-term exposure to air pollution is a cause of childhood asthma, but the evidence for a similar determination for adult asthma or COPD remains insufficient. Further research is needed to elucidate the exact biological mechanism underlying incident childhood asthma, and the specific air pollutant that causes it.
AB - Although it is well accepted that air pollution exposure exacerbates preexisting airway disease, it has not been firmly established that long-term pollution exposure increases the risk of new-onset asthma or chronic obstruction pulmonary disease (COPD). This Workshop brought together experts on mechanistic, epidemiological, and clinical aspects of airway disease to review current knowledge regarding whether air pollution is a causal factor in the development of asthma and/or COPD. Speakers presented recent evidence in their respective areas of expertise related to air pollution and new airway disease incidence, followed by interactive discussions. A writing committee summarized their collective findings. The Epidemiology Group found that long-term exposure to air pollution, especially metrics of traffic-related air pollution such as nitrogen dioxide and black carbon, is associated with onset of childhood asthma. However, the evidence for a causal role in adultonset asthma or COPD remains insufficient. The Mechanistic Group concluded that air pollution exposure can cause airway remodeling, which can lead to asthma or COPD, as well as asthma-like phenotypes that worsen with long-term exposure to air pollution, especially fine particulate matter and ozone. The Clinical Group concluded that air pollution is a plausible contributor to the onset of both asthma and COPD. Available evidence indicates that long-term exposure to air pollution is a cause of childhood asthma, but the evidence for a similar determination for adult asthma or COPD remains insufficient. Further research is needed to elucidate the exact biological mechanism underlying incident childhood asthma, and the specific air pollutant that causes it.
KW - Air pollution
KW - Asthma
KW - COPD
KW - New-onset airway disease
UR - http://www.scopus.com/inward/record.url?scp=85082731484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082731484&partnerID=8YFLogxK
U2 - 10.1513/AnnalsATS.202001-046ST
DO - 10.1513/AnnalsATS.202001-046ST
M3 - Article
C2 - 32233861
AN - SCOPUS:85082731484
VL - 17
SP - 387
EP - 398
JO - Annals of the American Thoracic Society
JF - Annals of the American Thoracic Society
SN - 2325-6621
IS - 4
ER -