Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study

Jason Y.Y. Wong, Helene G Margolis, Mitchell Machiela, Weiyin Zhou, Michelle C. Odden, Bruce M. Psaty, John A Robbins, Rena R. Jones, Jerome I. Rotter, Stephen J. Chanock, Nathaniel Rothman, Qing Lan, Jennifer S. Lee

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. Objective: We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY. Methods: We analyzed baseline (1989–1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. Particulate matter ≤10 μm (PM10), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants’ monthly residential exposure. mLOY was detected with standard methods using signal intensity (median log-R ratio (mLRR)) of the male-specific chromosome Y regions from Illumina array data. Linear regression models were used to evaluate relations between mean exposure in the prior year, age, smoking and continuous mLRR. Results: Increased PM10 was associated with mLOY, namely decreased mLRR (p-trend = 0.03). Compared with the lowest tertile (≤28.5 μg/m3), the middle (28.5–31.0 μg/m3; β = −0.0044, p = 0.09) and highest (≥31 μg/m3; β = −0.0054, p = 0.04) tertiles had decreased mLRR, adjusted for age, clinic, race/cohort, smoking status and pack-years. Additionally, increasing age (β = −0.00035, p = 0.06) and smoking pack-years (β = −0.00011, p = 1.4E−3) were associated with decreased mLRR, adjusted for each other and race/cohort. No significant associations were found for other pollutants. Conclusions: PM10 may increase leukocyte mLOY, a marker of genomic instability. The sample size was modest and replication is warranted.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalEnvironment International
Volume116
DOIs
StatePublished - Jul 1 2018

Keywords

  • Air pollution
  • Genetic mosaicism
  • Genomic instability
  • Loss of chromosome Y
  • PM

ASJC Scopus subject areas

  • Environmental Science(all)

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    Wong, J. Y. Y., Margolis, H. G., Machiela, M., Zhou, W., Odden, M. C., Psaty, B. M., Robbins, J. A., Jones, R. R., Rotter, J. I., Chanock, S. J., Rothman, N., Lan, Q., & Lee, J. S. (2018). Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study. Environment International, 116, 239-247. https://doi.org/10.1016/j.envint.2018.04.030