Outcomes of dogs with grade 3 mast cell tumors: 43 cases (1997-2007)

Carrie Tupper Hume, Matti Kiupel, Lora Rigatti, Frances S. Shofer, Katherine A Skorupski, Karin U. Sorenmo

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This study reports the outcomes of dogs with grade 3 mast cell tumors (MCTs). Clinical and histopathological data were available for 43 dogs. Median progression-free survival (PFS) and overall survival (OS) were 133 and 257 days, respectively. Tumor size, lymph node (LN) status, and mitotic index (MI) significantly influenced PFS in univariate analysis. Tumor size and LN status remained significant in the multivariate analysis. Lymph node status, local tumor control, LN treatment, and MI significantly influenced OS in univariate analysis but only LN status remained significant in multivariate analysis. These results confirm that locoregional control improves outcomes in patients with grade 3 MCTs.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalJournal of the American Animal Hospital Association
Volume47
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

mast cells
Mast Cells
lymph nodes
Lymph Nodes
Dogs
neoplasms
dogs
Mitotic Index
Neoplasms
multivariate analysis
Disease-Free Survival
Multivariate Analysis
Survival
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Small Animals

Cite this

Outcomes of dogs with grade 3 mast cell tumors : 43 cases (1997-2007). / Hume, Carrie Tupper; Kiupel, Matti; Rigatti, Lora; Shofer, Frances S.; Skorupski, Katherine A; Sorenmo, Karin U.

In: Journal of the American Animal Hospital Association, Vol. 47, No. 1, 01.2011, p. 37-44.

Research output: Contribution to journalArticle

Hume, Carrie Tupper ; Kiupel, Matti ; Rigatti, Lora ; Shofer, Frances S. ; Skorupski, Katherine A ; Sorenmo, Karin U. / Outcomes of dogs with grade 3 mast cell tumors : 43 cases (1997-2007). In: Journal of the American Animal Hospital Association. 2011 ; Vol. 47, No. 1. pp. 37-44.
@article{c3b44c2be7f54550a87a6a026fa5afd3,
title = "Outcomes of dogs with grade 3 mast cell tumors: 43 cases (1997-2007)",
abstract = "This study reports the outcomes of dogs with grade 3 mast cell tumors (MCTs). Clinical and histopathological data were available for 43 dogs. Median progression-free survival (PFS) and overall survival (OS) were 133 and 257 days, respectively. Tumor size, lymph node (LN) status, and mitotic index (MI) significantly influenced PFS in univariate analysis. Tumor size and LN status remained significant in the multivariate analysis. Lymph node status, local tumor control, LN treatment, and MI significantly influenced OS in univariate analysis but only LN status remained significant in multivariate analysis. These results confirm that locoregional control improves outcomes in patients with grade 3 MCTs.",
author = "Hume, {Carrie Tupper} and Matti Kiupel and Lora Rigatti and Shofer, {Frances S.} and Skorupski, {Katherine A} and Sorenmo, {Karin U.}",
year = "2011",
month = "1",
doi = "10.5326/JAAHA-MS-5557",
language = "English (US)",
volume = "47",
pages = "37--44",
journal = "Journal of the American Animal Hospital Association",
issn = "0587-2871",
publisher = "American Animal Hospital Association",
number = "1",

}

TY - JOUR

T1 - Outcomes of dogs with grade 3 mast cell tumors

T2 - 43 cases (1997-2007)

AU - Hume, Carrie Tupper

AU - Kiupel, Matti

AU - Rigatti, Lora

AU - Shofer, Frances S.

AU - Skorupski, Katherine A

AU - Sorenmo, Karin U.

PY - 2011/1

Y1 - 2011/1

N2 - This study reports the outcomes of dogs with grade 3 mast cell tumors (MCTs). Clinical and histopathological data were available for 43 dogs. Median progression-free survival (PFS) and overall survival (OS) were 133 and 257 days, respectively. Tumor size, lymph node (LN) status, and mitotic index (MI) significantly influenced PFS in univariate analysis. Tumor size and LN status remained significant in the multivariate analysis. Lymph node status, local tumor control, LN treatment, and MI significantly influenced OS in univariate analysis but only LN status remained significant in multivariate analysis. These results confirm that locoregional control improves outcomes in patients with grade 3 MCTs.

AB - This study reports the outcomes of dogs with grade 3 mast cell tumors (MCTs). Clinical and histopathological data were available for 43 dogs. Median progression-free survival (PFS) and overall survival (OS) were 133 and 257 days, respectively. Tumor size, lymph node (LN) status, and mitotic index (MI) significantly influenced PFS in univariate analysis. Tumor size and LN status remained significant in the multivariate analysis. Lymph node status, local tumor control, LN treatment, and MI significantly influenced OS in univariate analysis but only LN status remained significant in multivariate analysis. These results confirm that locoregional control improves outcomes in patients with grade 3 MCTs.

UR - http://www.scopus.com/inward/record.url?scp=78650804772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650804772&partnerID=8YFLogxK

U2 - 10.5326/JAAHA-MS-5557

DO - 10.5326/JAAHA-MS-5557

M3 - Article

C2 - 21164163

AN - SCOPUS:78650804772

VL - 47

SP - 37

EP - 44

JO - Journal of the American Animal Hospital Association

JF - Journal of the American Animal Hospital Association

SN - 0587-2871

IS - 1

ER -