Outcome of surgical versus medical treatment of dogs with beta cell neoplasia: 39 cases (1990-1097)

Regina L. Tobin, Richard W Nelson, Michael D. Lucroy, John D. Wooldridge, Edward C Feldman

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Objective - To compare outcome of surgical versus medical treatment of dogs with beta cell neoplasia. Design - Retrospective study. Animals - 39 dogs with clinical signs of hypoglycemia and serum glucose and insulin concentrations consistent with a diagnosis of beta cell neoplasia. Procedure - Information on signalment; clinical history; physical examination findings; results of CBC, serum biochemical analyses, and urinalysis; serum glucose and insulin concentrations; results of thoracic radiography and abdominal ultrasonography; treatment and treatment complications; survival time; and cause of death were obtained from medical records. Results - 26 dogs underwent exploratory celiotomy and partial pancreatectomy; 13 dogs were treated medically (ie, dietary change and prednisone). Median survival time was significantly longer for dogs treated surgically than for dogs treated medically. Significant differences were not found in mean age, body weight, duration of clinical signs prior to diagnosis, serum glucose and insulin concentration, or results of other serum biochemical tests between dogs treated surgically and dogs treated medically; also, there was no significant correlation between any of these parameters and survival time for either group of dogs. Conclusions and Clinical Relevance - Results suggest that exploratory celiotomy and partial pancreatectomy are indicated once a tentative diagnosis of beta cell neoplasia is established in dogs. (J Am Vet Med Assoc 1999;215:226-230).

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume215
Issue number2
StatePublished - Jul 15 1999

ASJC Scopus subject areas

  • veterinary(all)

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