Abstract
Objective - To compare outcome of surgical versus medical treatment of dogs with beta cell neoplasia. Design - Retrospective study. Animals - 39 dogs with clinical signs of hypoglycemia and serum glucose and insulin concentrations consistent with a diagnosis of beta cell neoplasia. Procedure - Information on signalment; clinical history; physical examination findings; results of CBC, serum biochemical analyses, and urinalysis; serum glucose and insulin concentrations; results of thoracic radiography and abdominal ultrasonography; treatment and treatment complications; survival time; and cause of death were obtained from medical records. Results - 26 dogs underwent exploratory celiotomy and partial pancreatectomy; 13 dogs were treated medically (ie, dietary change and prednisone). Median survival time was significantly longer for dogs treated surgically than for dogs treated medically. Significant differences were not found in mean age, body weight, duration of clinical signs prior to diagnosis, serum glucose and insulin concentration, or results of other serum biochemical tests between dogs treated surgically and dogs treated medically; also, there was no significant correlation between any of these parameters and survival time for either group of dogs. Conclusions and Clinical Relevance - Results suggest that exploratory celiotomy and partial pancreatectomy are indicated once a tentative diagnosis of beta cell neoplasia is established in dogs. (J Am Vet Med Assoc 1999;215:226-230).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 226-230 |
| Number of pages | 5 |
| Journal | Journal of the American Veterinary Medical Association |
| Volume | 215 |
| Issue number | 2 |
| State | Published - Jul 15 1999 |
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ASJC Scopus subject areas
- veterinary(all)
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Outcome of surgical versus medical treatment of dogs with beta cell neoplasia : 39 cases (1990-1097). / Tobin, Regina L.; Nelson, Richard W; Lucroy, Michael D.; Wooldridge, John D.; Feldman, Edward C.
In: Journal of the American Veterinary Medical Association, Vol. 215, No. 2, 15.07.1999, p. 226-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outcome of surgical versus medical treatment of dogs with beta cell neoplasia
T2 - 39 cases (1990-1097)
AU - Tobin, Regina L.
AU - Nelson, Richard W
AU - Lucroy, Michael D.
AU - Wooldridge, John D.
AU - Feldman, Edward C
PY - 1999/7/15
Y1 - 1999/7/15
N2 - Objective - To compare outcome of surgical versus medical treatment of dogs with beta cell neoplasia. Design - Retrospective study. Animals - 39 dogs with clinical signs of hypoglycemia and serum glucose and insulin concentrations consistent with a diagnosis of beta cell neoplasia. Procedure - Information on signalment; clinical history; physical examination findings; results of CBC, serum biochemical analyses, and urinalysis; serum glucose and insulin concentrations; results of thoracic radiography and abdominal ultrasonography; treatment and treatment complications; survival time; and cause of death were obtained from medical records. Results - 26 dogs underwent exploratory celiotomy and partial pancreatectomy; 13 dogs were treated medically (ie, dietary change and prednisone). Median survival time was significantly longer for dogs treated surgically than for dogs treated medically. Significant differences were not found in mean age, body weight, duration of clinical signs prior to diagnosis, serum glucose and insulin concentration, or results of other serum biochemical tests between dogs treated surgically and dogs treated medically; also, there was no significant correlation between any of these parameters and survival time for either group of dogs. Conclusions and Clinical Relevance - Results suggest that exploratory celiotomy and partial pancreatectomy are indicated once a tentative diagnosis of beta cell neoplasia is established in dogs. (J Am Vet Med Assoc 1999;215:226-230).
AB - Objective - To compare outcome of surgical versus medical treatment of dogs with beta cell neoplasia. Design - Retrospective study. Animals - 39 dogs with clinical signs of hypoglycemia and serum glucose and insulin concentrations consistent with a diagnosis of beta cell neoplasia. Procedure - Information on signalment; clinical history; physical examination findings; results of CBC, serum biochemical analyses, and urinalysis; serum glucose and insulin concentrations; results of thoracic radiography and abdominal ultrasonography; treatment and treatment complications; survival time; and cause of death were obtained from medical records. Results - 26 dogs underwent exploratory celiotomy and partial pancreatectomy; 13 dogs were treated medically (ie, dietary change and prednisone). Median survival time was significantly longer for dogs treated surgically than for dogs treated medically. Significant differences were not found in mean age, body weight, duration of clinical signs prior to diagnosis, serum glucose and insulin concentration, or results of other serum biochemical tests between dogs treated surgically and dogs treated medically; also, there was no significant correlation between any of these parameters and survival time for either group of dogs. Conclusions and Clinical Relevance - Results suggest that exploratory celiotomy and partial pancreatectomy are indicated once a tentative diagnosis of beta cell neoplasia is established in dogs. (J Am Vet Med Assoc 1999;215:226-230).
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UR - http://www.scopus.com/inward/citedby.url?scp=0033565051&partnerID=8YFLogxK
M3 - Article
C2 - 10416477
AN - SCOPUS:0033565051
VL - 215
SP - 226
EP - 230
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
SN - 0003-1488
IS - 2
ER -