Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To determine the outcome of preterm infants whose cystic periventricular leukomalacia “disappeared” on serial screening cranial imaging studies. Study design: Infants ≤26 weeks of gestation born between 2002 and 2012 who had cranial imaging studies at least twice, the most abnormal study at <28 days of age and another closest to 36 weeks, were reviewed. The outcome of late death (after 36 weeks postmenstrual age) or neurodevelopmental impairment (NDI) in surviving infants at 18-26 months corrected age was compared between the infants with no cystic periventricular leukomalacia on both studies and cystic periventricular leukomalacia that disappeared (cystic periventricular leukomalacia at <28 days but not at 36 weeks), persisted (cystic periventricular leukomalacia on both studies), or appeared late (cystic periventricular leukomalacia only at 36 weeks). Predictors of NDI were evaluated by logistic regression. Results: Of 7063 eligible infants, 433 (6.1%) had cystic periventricular leukomalacia. Among the 433 infants with cystic periventricular leukomalacia, cystic periventricular leukomalacia disappeared in 76 (18%), persisted in 87 (20%), and 270 (62%) had late cystic periventricular leukomalacia. Loss to follow-up ranged between 3% and 13%. Death or NDI was more common in infants with disappeared cystic periventricular leukomalacia compared with those with no cystic periventricular leukomalacia (38 of 72 [53%] vs 1776 of 6376 [28%]; OR [95% CI] 2.8 [1.8-4.6]). Disappeared, persistent, and late cystic periventricular leukomalacia were all also independently associated with NDI (OR 1.17, 1.21, and 1.16, respectively). Conclusions: Infants with “disappeared” cystic periventricular leukomalacia are at increased risk of adverse outcome similar to infants with persistent or late cystic periventricular leukomalacia.

Original languageEnglish (US)
Pages (from-to)59-65.e3
JournalJournal of Pediatrics
Volume195
DOIs
StatePublished - Apr 1 2018
Externally publishedYes

Fingerprint

Periventricular Leukomalacia
Premature Infants

Keywords

  • cranial ultrasonography
  • cystic periventricular leukomalacia
  • neurodevelopmental impairment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (2018). Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. Journal of Pediatrics, 195, 59-65.e3. https://doi.org/10.1016/j.jpeds.2017.12.010

Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. / Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

In: Journal of Pediatrics, Vol. 195, 01.04.2018, p. 59-65.e3.

Research output: Contribution to journalArticle

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network 2018, 'Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age', Journal of Pediatrics, vol. 195, pp. 59-65.e3. https://doi.org/10.1016/j.jpeds.2017.12.010
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. Journal of Pediatrics. 2018 Apr 1;195:59-65.e3. https://doi.org/10.1016/j.jpeds.2017.12.010
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. / Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. In: Journal of Pediatrics. 2018 ; Vol. 195. pp. 59-65.e3.
@article{f0ad80db427740e09bc5aa4109102228,
title = "Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age",
abstract = "Objective: To determine the outcome of preterm infants whose cystic periventricular leukomalacia “disappeared” on serial screening cranial imaging studies. Study design: Infants ≤26 weeks of gestation born between 2002 and 2012 who had cranial imaging studies at least twice, the most abnormal study at <28 days of age and another closest to 36 weeks, were reviewed. The outcome of late death (after 36 weeks postmenstrual age) or neurodevelopmental impairment (NDI) in surviving infants at 18-26 months corrected age was compared between the infants with no cystic periventricular leukomalacia on both studies and cystic periventricular leukomalacia that disappeared (cystic periventricular leukomalacia at <28 days but not at 36 weeks), persisted (cystic periventricular leukomalacia on both studies), or appeared late (cystic periventricular leukomalacia only at 36 weeks). Predictors of NDI were evaluated by logistic regression. Results: Of 7063 eligible infants, 433 (6.1{\%}) had cystic periventricular leukomalacia. Among the 433 infants with cystic periventricular leukomalacia, cystic periventricular leukomalacia disappeared in 76 (18{\%}), persisted in 87 (20{\%}), and 270 (62{\%}) had late cystic periventricular leukomalacia. Loss to follow-up ranged between 3{\%} and 13{\%}. Death or NDI was more common in infants with disappeared cystic periventricular leukomalacia compared with those with no cystic periventricular leukomalacia (38 of 72 [53{\%}] vs 1776 of 6376 [28{\%}]; OR [95{\%} CI] 2.8 [1.8-4.6]). Disappeared, persistent, and late cystic periventricular leukomalacia were all also independently associated with NDI (OR 1.17, 1.21, and 1.16, respectively). Conclusions: Infants with “disappeared” cystic periventricular leukomalacia are at increased risk of adverse outcome similar to infants with persistent or late cystic periventricular leukomalacia.",
keywords = "cranial ultrasonography, cystic periventricular leukomalacia, neurodevelopmental impairment",
author = "{Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network} and Subrata Sarkar and Seetha Shankaran and John Barks and Do, {Barbara T.} and Laptook, {Abbot R.} and Abhik Das and Namasivayam Ambalavanan and {Van Meurs}, {Krisa P.} and Bell, {Edward F.} and Sanchez, {Pablo J.} and Hintz, {Susan R.} and Wyckoff, {Myra H.} and Stoll, {Barbara J.} and Carlo, {Waldemar A.} and Jobe, {Alan H.} and Caplan, {Michael S.} and Polin, {Richard A.} and Martin Keszler and William Oh and Vohr, {Betty R.} and Hensman, {Angelita M.} and Barbara Alksninis and Basso, {Kristin M.} and Robert Burke and Melinda Caskey and Katharine Johnson and Keszler, {Mary Lenore} and Knoll, {Andrea M.} and Leach, {Theresa M.} and Emilee Little and McGowan, {Elisabeth C.} and Elisa Vieira and Watson, {Victoria E.} and Suzy Ventura and Walsh, {Michele C.} and Fanaroff, {Avroy A.} and Hibbs, {Anna Marie} and Wilson-Costello, {Deanne E.} and Newman, {Nancy S.} and Payne, {Allison H.} and Siner, {Bonnie S.} and Monika Bhola and Gulgun Yalcinkaya and Friedman, {Harriet G.} and Truog, {William E.} and Pallotto, {Eugenia K.} and Kilbride, {Howard W.} and Cheri Gauldin and Anne Holmes and Satyanarayana Lakshminrusimha",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.jpeds.2017.12.010",
language = "English (US)",
volume = "195",
pages = "59--65.e3",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age

AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

AU - Sarkar, Subrata

AU - Shankaran, Seetha

AU - Barks, John

AU - Do, Barbara T.

AU - Laptook, Abbot R.

AU - Das, Abhik

AU - Ambalavanan, Namasivayam

AU - Van Meurs, Krisa P.

AU - Bell, Edward F.

AU - Sanchez, Pablo J.

AU - Hintz, Susan R.

AU - Wyckoff, Myra H.

AU - Stoll, Barbara J.

AU - Carlo, Waldemar A.

AU - Jobe, Alan H.

AU - Caplan, Michael S.

AU - Polin, Richard A.

AU - Keszler, Martin

AU - Oh, William

AU - Vohr, Betty R.

AU - Hensman, Angelita M.

AU - Alksninis, Barbara

AU - Basso, Kristin M.

AU - Burke, Robert

AU - Caskey, Melinda

AU - Johnson, Katharine

AU - Keszler, Mary Lenore

AU - Knoll, Andrea M.

AU - Leach, Theresa M.

AU - Little, Emilee

AU - McGowan, Elisabeth C.

AU - Vieira, Elisa

AU - Watson, Victoria E.

AU - Ventura, Suzy

AU - Walsh, Michele C.

AU - Fanaroff, Avroy A.

AU - Hibbs, Anna Marie

AU - Wilson-Costello, Deanne E.

AU - Newman, Nancy S.

AU - Payne, Allison H.

AU - Siner, Bonnie S.

AU - Bhola, Monika

AU - Yalcinkaya, Gulgun

AU - Friedman, Harriet G.

AU - Truog, William E.

AU - Pallotto, Eugenia K.

AU - Kilbride, Howard W.

AU - Gauldin, Cheri

AU - Holmes, Anne

AU - Lakshminrusimha, Satyanarayana

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Objective: To determine the outcome of preterm infants whose cystic periventricular leukomalacia “disappeared” on serial screening cranial imaging studies. Study design: Infants ≤26 weeks of gestation born between 2002 and 2012 who had cranial imaging studies at least twice, the most abnormal study at <28 days of age and another closest to 36 weeks, were reviewed. The outcome of late death (after 36 weeks postmenstrual age) or neurodevelopmental impairment (NDI) in surviving infants at 18-26 months corrected age was compared between the infants with no cystic periventricular leukomalacia on both studies and cystic periventricular leukomalacia that disappeared (cystic periventricular leukomalacia at <28 days but not at 36 weeks), persisted (cystic periventricular leukomalacia on both studies), or appeared late (cystic periventricular leukomalacia only at 36 weeks). Predictors of NDI were evaluated by logistic regression. Results: Of 7063 eligible infants, 433 (6.1%) had cystic periventricular leukomalacia. Among the 433 infants with cystic periventricular leukomalacia, cystic periventricular leukomalacia disappeared in 76 (18%), persisted in 87 (20%), and 270 (62%) had late cystic periventricular leukomalacia. Loss to follow-up ranged between 3% and 13%. Death or NDI was more common in infants with disappeared cystic periventricular leukomalacia compared with those with no cystic periventricular leukomalacia (38 of 72 [53%] vs 1776 of 6376 [28%]; OR [95% CI] 2.8 [1.8-4.6]). Disappeared, persistent, and late cystic periventricular leukomalacia were all also independently associated with NDI (OR 1.17, 1.21, and 1.16, respectively). Conclusions: Infants with “disappeared” cystic periventricular leukomalacia are at increased risk of adverse outcome similar to infants with persistent or late cystic periventricular leukomalacia.

AB - Objective: To determine the outcome of preterm infants whose cystic periventricular leukomalacia “disappeared” on serial screening cranial imaging studies. Study design: Infants ≤26 weeks of gestation born between 2002 and 2012 who had cranial imaging studies at least twice, the most abnormal study at <28 days of age and another closest to 36 weeks, were reviewed. The outcome of late death (after 36 weeks postmenstrual age) or neurodevelopmental impairment (NDI) in surviving infants at 18-26 months corrected age was compared between the infants with no cystic periventricular leukomalacia on both studies and cystic periventricular leukomalacia that disappeared (cystic periventricular leukomalacia at <28 days but not at 36 weeks), persisted (cystic periventricular leukomalacia on both studies), or appeared late (cystic periventricular leukomalacia only at 36 weeks). Predictors of NDI were evaluated by logistic regression. Results: Of 7063 eligible infants, 433 (6.1%) had cystic periventricular leukomalacia. Among the 433 infants with cystic periventricular leukomalacia, cystic periventricular leukomalacia disappeared in 76 (18%), persisted in 87 (20%), and 270 (62%) had late cystic periventricular leukomalacia. Loss to follow-up ranged between 3% and 13%. Death or NDI was more common in infants with disappeared cystic periventricular leukomalacia compared with those with no cystic periventricular leukomalacia (38 of 72 [53%] vs 1776 of 6376 [28%]; OR [95% CI] 2.8 [1.8-4.6]). Disappeared, persistent, and late cystic periventricular leukomalacia were all also independently associated with NDI (OR 1.17, 1.21, and 1.16, respectively). Conclusions: Infants with “disappeared” cystic periventricular leukomalacia are at increased risk of adverse outcome similar to infants with persistent or late cystic periventricular leukomalacia.

KW - cranial ultrasonography

KW - cystic periventricular leukomalacia

KW - neurodevelopmental impairment

UR - http://www.scopus.com/inward/record.url?scp=85041629736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041629736&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2017.12.010

DO - 10.1016/j.jpeds.2017.12.010

M3 - Article

C2 - 29398046

AN - SCOPUS:85041629736

VL - 195

SP - 59-65.e3

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -