Outcome of Metastatic and Recurrent Ovarian Dysgerminoma Using Radiation Therapy and Chemotherapy in a Dog

Research output: Contribution to journalArticle

Abstract

An 8 yr old female spayed poodle/terrier mixed-breed dog was referred for evaluation of a recurrent and metastatic ovarian dysgerminoma. A total dose of 20Gy was administered to both the mediastinal metastatic lesion and retroperitoneal recurrent dysgerminoma in five daily fractions of 4Gy. Acute side effects were mild and self-limiting. This was followed by several courses of chemotherapy using a variety of agents. Despite extensive disease, this patient was still alive at the time of publication, 524 days after presentation and 501 days following completion of radiation. This case report demonstrates tolerability and efficacy of palliative radiation and chemotherapy for this rare tumor type.

Original languageEnglish (US)
Pages (from-to)e55402
JournalJournal of the American Animal Hospital Association
Volume55
Issue number4
DOIs
StatePublished - Jul 1 2019

Fingerprint

Dysgerminoma
radiotherapy
drug therapy
Radiotherapy
Dogs
Radiation
Poodle (dog breed)
Drug Therapy
terriers
dogs
lesions (animal)
Publications
adverse effects
case studies
neoplasms
dosage
Neoplasms
mixed breeds

ASJC Scopus subject areas

  • Small Animals

Cite this

@article{0dec971a8a5d48e88914fe9b62a8d56d,
title = "Outcome of Metastatic and Recurrent Ovarian Dysgerminoma Using Radiation Therapy and Chemotherapy in a Dog",
abstract = "An 8 yr old female spayed poodle/terrier mixed-breed dog was referred for evaluation of a recurrent and metastatic ovarian dysgerminoma. A total dose of 20Gy was administered to both the mediastinal metastatic lesion and retroperitoneal recurrent dysgerminoma in five daily fractions of 4Gy. Acute side effects were mild and self-limiting. This was followed by several courses of chemotherapy using a variety of agents. Despite extensive disease, this patient was still alive at the time of publication, 524 days after presentation and 501 days following completion of radiation. This case report demonstrates tolerability and efficacy of palliative radiation and chemotherapy for this rare tumor type.",
author = "Wilcox, {Cassandra L.} and Hansen, {Katherine S} and Kent, {Michael S} and Phillips, {Kathryn L} and Jennifer Willcox",
year = "2019",
month = "7",
day = "1",
doi = "10.5326/JAAHA-MS-6893",
language = "English (US)",
volume = "55",
pages = "e55402",
journal = "Journal of the American Animal Hospital Association",
issn = "0587-2871",
publisher = "American Animal Hospital Association",
number = "4",

}

TY - JOUR

T1 - Outcome of Metastatic and Recurrent Ovarian Dysgerminoma Using Radiation Therapy and Chemotherapy in a Dog

AU - Wilcox, Cassandra L.

AU - Hansen, Katherine S

AU - Kent, Michael S

AU - Phillips, Kathryn L

AU - Willcox, Jennifer

PY - 2019/7/1

Y1 - 2019/7/1

N2 - An 8 yr old female spayed poodle/terrier mixed-breed dog was referred for evaluation of a recurrent and metastatic ovarian dysgerminoma. A total dose of 20Gy was administered to both the mediastinal metastatic lesion and retroperitoneal recurrent dysgerminoma in five daily fractions of 4Gy. Acute side effects were mild and self-limiting. This was followed by several courses of chemotherapy using a variety of agents. Despite extensive disease, this patient was still alive at the time of publication, 524 days after presentation and 501 days following completion of radiation. This case report demonstrates tolerability and efficacy of palliative radiation and chemotherapy for this rare tumor type.

AB - An 8 yr old female spayed poodle/terrier mixed-breed dog was referred for evaluation of a recurrent and metastatic ovarian dysgerminoma. A total dose of 20Gy was administered to both the mediastinal metastatic lesion and retroperitoneal recurrent dysgerminoma in five daily fractions of 4Gy. Acute side effects were mild and self-limiting. This was followed by several courses of chemotherapy using a variety of agents. Despite extensive disease, this patient was still alive at the time of publication, 524 days after presentation and 501 days following completion of radiation. This case report demonstrates tolerability and efficacy of palliative radiation and chemotherapy for this rare tumor type.

UR - http://www.scopus.com/inward/record.url?scp=85068488834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068488834&partnerID=8YFLogxK

U2 - 10.5326/JAAHA-MS-6893

DO - 10.5326/JAAHA-MS-6893

M3 - Article

VL - 55

SP - e55402

JO - Journal of the American Animal Hospital Association

JF - Journal of the American Animal Hospital Association

SN - 0587-2871

IS - 4

ER -