Outcome of dogs with intranasal lymphoma treated with various radiation and chemotherapy protocols

24 cases

Rebecca George, Annette Smith, Stephanie Schleis, William Brawner, Gregory Almond, Michael S Kent, Jackie Wypij, Juan Borrego, Antony Moore, Michele Keyerleber, Sarah Kraiza

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tumors of the nasal cavity comprise approximately 1% of all neoplasms in dogs. Canine intranasal lymphoma is rare and reports evaluating the outcome of treatment are lacking. The goal of this observational, descriptive, multi-institutional study was to evaluate the overall median survival times (MSTs) in a group of dogs with intranasal lymphoma that were treated with irradiation and/or chemotherapy. Dogs meeting these inclusion criteria were retrospectively recruited from medical archives at multiple institutions. Eighteen cases of intermediate to high grade intranasal lymphoma and six cases of low-grade intranasal lymphoma were identified. The date of diagnosis, method of diagnosis, treatment received (radiation and/or chemotherapy protocols), and date of death were recorded. Kaplan-Meier survival analysis was performed on the intermediate to high grade group to calculate overall MST. Log-rank tests were performed to compare effects of treatment with radiation therapy ± chemotherapy and chemotherapy alone. Kaplan-Meier survival analysis was performed separately on the low-grade group. The overall MST was 375 days for the intermediate to high grade group. Cases treated with radiation ± chemotherapy had an MST of 455 days (n = 12) and those treated with chemotherapy alone (n = 6) had an MST of 157 days in the intermediate to high grade group. The MST was 823 days for the low-grade group. Results support the use of radiation therapy for treatment of canine intranasal lymphoma, however a randomized, controlled, clinical trial would be needed for more definitive recommendations. The role of adjunctive chemotherapy also may require further investigation.

Original languageEnglish (US)
JournalVeterinary Radiology and Ultrasound
DOIs
StateAccepted/In press - 2016

Fingerprint

lymphoma
drug therapy
Lymphoma
Dogs
Radiation
Drug Therapy
dogs
Kaplan-Meier Estimate
radiotherapy
Survival Analysis
Non-Hodgkin's Lymphoma
Canidae
Radiotherapy
neoplasms
randomized clinical trials
nasal cavity
Nasal Cavity
Neoplasms
Therapeutics
Randomized Controlled Trials

Keywords

  • Canine
  • Chemotherapy
  • Intranasal
  • Lymphoma
  • Radiation

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Outcome of dogs with intranasal lymphoma treated with various radiation and chemotherapy protocols : 24 cases. / George, Rebecca; Smith, Annette; Schleis, Stephanie; Brawner, William; Almond, Gregory; Kent, Michael S; Wypij, Jackie; Borrego, Juan; Moore, Antony; Keyerleber, Michele; Kraiza, Sarah.

In: Veterinary Radiology and Ultrasound, 2016.

Research output: Contribution to journalArticle

George, R, Smith, A, Schleis, S, Brawner, W, Almond, G, Kent, MS, Wypij, J, Borrego, J, Moore, A, Keyerleber, M & Kraiza, S 2016, 'Outcome of dogs with intranasal lymphoma treated with various radiation and chemotherapy protocols: 24 cases', Veterinary Radiology and Ultrasound. https://doi.org/10.1111/vru.12318
George, Rebecca ; Smith, Annette ; Schleis, Stephanie ; Brawner, William ; Almond, Gregory ; Kent, Michael S ; Wypij, Jackie ; Borrego, Juan ; Moore, Antony ; Keyerleber, Michele ; Kraiza, Sarah. / Outcome of dogs with intranasal lymphoma treated with various radiation and chemotherapy protocols : 24 cases. In: Veterinary Radiology and Ultrasound. 2016.
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