Outcome after Renal Transplantation in 26 Dogs

Katrina Hopper, Margo L. Mehl, Philip H Kass, Andrew Kyles, Clare R. Gregory

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: To evaluate clinical outcome in dogs after renal transplantation and determine predictors of outcome. Study Design: Retrospective case series. Animals: Dogs (n = 26) that had renal allograft transplantation. Methods: Medical records (1994-2006) of 26 consecutive cases of dogs that had kidney transplantation were reviewed. History, signalment, pre- and postoperative clinicopathologic and monitoring variables, postoperative complications, immunosuppressive therapy, and survival were recorded. Results: Median survival was 24 days (range, 0.5 to 4014 days) with a probability of survival to 15 days of 50% and the 100-day survival probability was 36%. Cause of death was attributed to thromboembolic disease in 8 dogs, infection in 6 dogs, and rejection in 1 dog. The only factor significantly associated with an increased likelihood of death was increasing age at time of surgery (P = .024). Conclusions: Canine renal transplantation in clinical patients is associated with a high morbidity and mortality and increasing recipient age has a negative association with outcome. Thromboembolic complications are a major cause of death in the immediate postoperative period and effective anticoagulation protocols may greatly improve survival in the future.

Original languageEnglish (US)
Pages (from-to)316-327
Number of pages12
JournalVeterinary Surgery
Volume41
Issue number3
DOIs
StatePublished - Apr 2012

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kidney transplant
Kidney Transplantation
Dogs
dogs
Survival
death
Cause of Death
immunosuppressive agents
Immunosuppressive Agents
allografting
postoperative complications
Postoperative Period
Medical Records
Allografts
Canidae
Retrospective Studies
morbidity
History
Morbidity
surgery

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Outcome after Renal Transplantation in 26 Dogs. / Hopper, Katrina; Mehl, Margo L.; Kass, Philip H; Kyles, Andrew; Gregory, Clare R.

In: Veterinary Surgery, Vol. 41, No. 3, 04.2012, p. 316-327.

Research output: Contribution to journalArticle

Hopper, Katrina ; Mehl, Margo L. ; Kass, Philip H ; Kyles, Andrew ; Gregory, Clare R. / Outcome after Renal Transplantation in 26 Dogs. In: Veterinary Surgery. 2012 ; Vol. 41, No. 3. pp. 316-327.
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