OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

Zhengkui Zhang, Jinjin Du, Shuai Wang, Li Shao, Ke Jin, Fang Li, Bajin Wei, Wei Ding, Peifen Fu, Hans van Dam, Aijun Wang, Jin Jin, Chen Ding, Bing Yang, Min Zheng, Xin Hua Feng, Kun Liang Guan, Long Zhang

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Zhang et al. identified OTUB2 as a cancer stemness and metastasis-promoting factor that deubiquitinates and activates YAP/TAZ independent of the Hippo signaling. OTUB2 was induced by EGF/KRAS to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ through a yet-unknown SUMO-interacting motif (SIM).

Original languageEnglish (US)
Pages (from-to)7-21.e7
JournalMolecular Cell
Volume73
Issue number1
DOIs
StatePublished - Jan 3 2019

Keywords

  • deubiquitination
  • metastasis
  • OTUB2
  • SUMOylation
  • YAP/TAZ

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ'. Together they form a unique fingerprint.

  • Cite this

    Zhang, Z., Du, J., Wang, S., Shao, L., Jin, K., Li, F., Wei, B., Ding, W., Fu, P., van Dam, H., Wang, A., Jin, J., Ding, C., Yang, B., Zheng, M., Feng, X. H., Guan, K. L., & Zhang, L. (2019). OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Molecular Cell, 73(1), 7-21.e7. https://doi.org/10.1016/j.molcel.2018.10.030