Abstract
Otitis externa is a common symptom of Langerhans' cell histiocytosis, and occurs in half of all children with the disease. Previous treatment regima have been either unsuccessful, or associated with undesirable side-effects. This study describes the successful use of topical 20% nitrogen mustard ear drops in the management of five children who had Langerhans' cell histiocytosis with otitis externa. All of them had previously been resistant to other forms of treatment. The children were aged between 6 months and 6 years. The otitis externa free period to date is up to 5 years. Topical nitrogen mustard ear drops are rapidly effective, can be administered at home, have not caused any adverse effects, and are of long-term benefit.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 57-61 |
| Number of pages | 5 |
| Journal | International Journal of Pediatric Otorhinolaryngology |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- Langerhans' cell histiocytosis
- Nitrogen mustard
- Otitis externa
- Paediatric
- Topical treatment
ASJC Scopus subject areas
- Otorhinolaryngology
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine
- Surgery
Cite this
Otitis externa in Langerhans' cell histiocytosis - The successful use of topical nitrogen mustard. / Birchall, M. A.
In: International Journal of Pediatric Otorhinolaryngology, Vol. 30, No. 2, 1994, p. 57-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Otitis externa in Langerhans' cell histiocytosis - The successful use of topical nitrogen mustard
AU - Birchall, M. A.
PY - 1994
Y1 - 1994
N2 - Otitis externa is a common symptom of Langerhans' cell histiocytosis, and occurs in half of all children with the disease. Previous treatment regima have been either unsuccessful, or associated with undesirable side-effects. This study describes the successful use of topical 20% nitrogen mustard ear drops in the management of five children who had Langerhans' cell histiocytosis with otitis externa. All of them had previously been resistant to other forms of treatment. The children were aged between 6 months and 6 years. The otitis externa free period to date is up to 5 years. Topical nitrogen mustard ear drops are rapidly effective, can be administered at home, have not caused any adverse effects, and are of long-term benefit.
AB - Otitis externa is a common symptom of Langerhans' cell histiocytosis, and occurs in half of all children with the disease. Previous treatment regima have been either unsuccessful, or associated with undesirable side-effects. This study describes the successful use of topical 20% nitrogen mustard ear drops in the management of five children who had Langerhans' cell histiocytosis with otitis externa. All of them had previously been resistant to other forms of treatment. The children were aged between 6 months and 6 years. The otitis externa free period to date is up to 5 years. Topical nitrogen mustard ear drops are rapidly effective, can be administered at home, have not caused any adverse effects, and are of long-term benefit.
KW - Langerhans' cell histiocytosis
KW - Nitrogen mustard
KW - Otitis externa
KW - Paediatric
KW - Topical treatment
UR - http://www.scopus.com/inward/record.url?scp=28044462942&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28044462942&partnerID=8YFLogxK
U2 - 10.1016/0165-5876(94)90197-X
DO - 10.1016/0165-5876(94)90197-X
M3 - Article
C2 - 8063500
AN - SCOPUS:28044462942
VL - 30
SP - 57
EP - 61
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
SN - 0165-5876
IS - 2
ER -