Osteosarcoma following tibial plateau leveling osteotomy in dogs: 29 cases (1997-2011)

Laura E. Selmic, Stewart D. Ryan, Sarah E. Boston, Julius M. Liptak, William T Culp, Angela J. Sartor, Cassandra Y. Prpich, Stephen J. Withrow

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective-To determine the signalment, tibial plateau leveling osteotomy (TPLO) plate type, clinical staging information, treatment, and oncological outcome in dogs that developed osteosarcoma at the proximal aspect of the tibia following TPLO and to calculate the interval between TPLO and osteosarcoma diagnosis. Design-Multi-institutional retrospective case series. Animals-29 dogs. Procedures-Medical records from 8 participating institutions were searched for dogs that developed osteosarcoma (confirmed through cytologic or histologic evaluation) at previous TPLO sites. Signalment, TPLO details, staging tests, treatment data, and outcome information were recorded. Descriptive statistics were calculated, and disease-free intervals and survival times were evaluated by means of Kaplan-Meier analysis. Results-29 dogs met the inclusion criteria. The mean age was 9.2 years and mean weight was 45.1 kg (99.2 lb) at the time of osteosarcoma diagnosis. Most dogs had swelling over the proximal aspect of the tibia (17/21) and lameness of the affected limb (28/29). The mean interval between TPLO and osteosarcoma diagnosis was 5.3 years. One type of cast stainless steel TPLO plate was used in most (18) dogs; the remaining dogs had received plates of wrought stainless steel (n = 4) or unrecorded type (7). Twenty-three of 29 dogs underwent treatment for osteosarcoma. Median survival time for 10 dogs that underwent amputation of the affected limb and received ≥ 1 chemotherapeutic treatment was 313 days. Conclusions and Clinical Relevance-Results supported that osteosarcoma should be a differential diagnosis for dogs with a history of TPLO that later develop lameness and swelling at the previous surgical site. Oncological outcome following amputation and chemotherapy appeared to be similar to outcomes previously reported for dogs with appendicular osteosarcoma.

Original languageEnglish (US)
Pages (from-to)1053-1059
Number of pages7
JournalJournal of the American Veterinary Medical Association
Volume244
Issue number9
DOIs
StatePublished - 2014

Fingerprint

osteosarcoma
Osteosarcoma
Osteotomy
plateaus
Dogs
dogs
amputation
Stainless Steel
stainless steel
limbs (animal)
tibia
Tibia
Amputation
lameness
osteotomy
Extremities
Kaplan-Meier Estimate
drug therapy
Disease-Free Survival
Medical Records

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

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Osteosarcoma following tibial plateau leveling osteotomy in dogs : 29 cases (1997-2011). / Selmic, Laura E.; Ryan, Stewart D.; Boston, Sarah E.; Liptak, Julius M.; Culp, William T; Sartor, Angela J.; Prpich, Cassandra Y.; Withrow, Stephen J.

In: Journal of the American Veterinary Medical Association, Vol. 244, No. 9, 2014, p. 1053-1059.

Research output: Contribution to journalArticle

Selmic, LE, Ryan, SD, Boston, SE, Liptak, JM, Culp, WT, Sartor, AJ, Prpich, CY & Withrow, SJ 2014, 'Osteosarcoma following tibial plateau leveling osteotomy in dogs: 29 cases (1997-2011)', Journal of the American Veterinary Medical Association, vol. 244, no. 9, pp. 1053-1059. https://doi.org/10.2460/javma.244.9.1053
Selmic, Laura E. ; Ryan, Stewart D. ; Boston, Sarah E. ; Liptak, Julius M. ; Culp, William T ; Sartor, Angela J. ; Prpich, Cassandra Y. ; Withrow, Stephen J. / Osteosarcoma following tibial plateau leveling osteotomy in dogs : 29 cases (1997-2011). In: Journal of the American Veterinary Medical Association. 2014 ; Vol. 244, No. 9. pp. 1053-1059.
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abstract = "Objective-To determine the signalment, tibial plateau leveling osteotomy (TPLO) plate type, clinical staging information, treatment, and oncological outcome in dogs that developed osteosarcoma at the proximal aspect of the tibia following TPLO and to calculate the interval between TPLO and osteosarcoma diagnosis. Design-Multi-institutional retrospective case series. Animals-29 dogs. Procedures-Medical records from 8 participating institutions were searched for dogs that developed osteosarcoma (confirmed through cytologic or histologic evaluation) at previous TPLO sites. Signalment, TPLO details, staging tests, treatment data, and outcome information were recorded. Descriptive statistics were calculated, and disease-free intervals and survival times were evaluated by means of Kaplan-Meier analysis. Results-29 dogs met the inclusion criteria. The mean age was 9.2 years and mean weight was 45.1 kg (99.2 lb) at the time of osteosarcoma diagnosis. Most dogs had swelling over the proximal aspect of the tibia (17/21) and lameness of the affected limb (28/29). The mean interval between TPLO and osteosarcoma diagnosis was 5.3 years. One type of cast stainless steel TPLO plate was used in most (18) dogs; the remaining dogs had received plates of wrought stainless steel (n = 4) or unrecorded type (7). Twenty-three of 29 dogs underwent treatment for osteosarcoma. Median survival time for 10 dogs that underwent amputation of the affected limb and received ≥ 1 chemotherapeutic treatment was 313 days. Conclusions and Clinical Relevance-Results supported that osteosarcoma should be a differential diagnosis for dogs with a history of TPLO that later develop lameness and swelling at the previous surgical site. Oncological outcome following amputation and chemotherapy appeared to be similar to outcomes previously reported for dogs with appendicular osteosarcoma.",
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AU - Selmic, Laura E.

AU - Ryan, Stewart D.

AU - Boston, Sarah E.

AU - Liptak, Julius M.

AU - Culp, William T

AU - Sartor, Angela J.

AU - Prpich, Cassandra Y.

AU - Withrow, Stephen J.

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AB - Objective-To determine the signalment, tibial plateau leveling osteotomy (TPLO) plate type, clinical staging information, treatment, and oncological outcome in dogs that developed osteosarcoma at the proximal aspect of the tibia following TPLO and to calculate the interval between TPLO and osteosarcoma diagnosis. Design-Multi-institutional retrospective case series. Animals-29 dogs. Procedures-Medical records from 8 participating institutions were searched for dogs that developed osteosarcoma (confirmed through cytologic or histologic evaluation) at previous TPLO sites. Signalment, TPLO details, staging tests, treatment data, and outcome information were recorded. Descriptive statistics were calculated, and disease-free intervals and survival times were evaluated by means of Kaplan-Meier analysis. Results-29 dogs met the inclusion criteria. The mean age was 9.2 years and mean weight was 45.1 kg (99.2 lb) at the time of osteosarcoma diagnosis. Most dogs had swelling over the proximal aspect of the tibia (17/21) and lameness of the affected limb (28/29). The mean interval between TPLO and osteosarcoma diagnosis was 5.3 years. One type of cast stainless steel TPLO plate was used in most (18) dogs; the remaining dogs had received plates of wrought stainless steel (n = 4) or unrecorded type (7). Twenty-three of 29 dogs underwent treatment for osteosarcoma. Median survival time for 10 dogs that underwent amputation of the affected limb and received ≥ 1 chemotherapeutic treatment was 313 days. Conclusions and Clinical Relevance-Results supported that osteosarcoma should be a differential diagnosis for dogs with a history of TPLO that later develop lameness and swelling at the previous surgical site. Oncological outcome following amputation and chemotherapy appeared to be similar to outcomes previously reported for dogs with appendicular osteosarcoma.

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