Abstract
The US Preventive Services Task Force (USPSTF) recommends osteoporosis screening for women younger than 65 years whose 10-year predicted risk of major osteoporotic fracture is ≥9.3%. For identifying screening candidates among women aged 50 to 64 years, it is uncertain how the USPSTF strategy compares with the Osteoporosis Self-Assessment Tool (OST) and the Simple Calculated Osteoporosis Risk Estimate (SCORE). We examined data (1994 to 2012) from 5165 Women's Health Initiative participants aged 50 to 64 years. For the USPSTF (Fracture Risk Assessment Tool [FRAX] major fracture risk ≥9.3% calculated without bone mineral density [BMD]), OST (score <2), and SCORE (score >7) strategies, we assessed sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) to discriminate between those with and without femoral neck (FN) T-score ≤-2.5. Sensitivity, specificity, and AUC for identifying FN T-score ≤-2.5 were 34.1%, 85.8%, and 0.60 for USPSTF (FRAX); 74.0%, 70.8%, and 0.72 for SCORE; and 79.8%, 66.3%, and 0.73 for OST. The USPSTF strategy identified about one-third of women aged 50 to 64 years with FN T-scores ≤-2.5. Among women aged 50 to 64 years, the USPSTF strategy was modestly better than chance alone and inferior to conventional SCORE and OST strategies in discriminating between women with and without FN T-score ≤-2.5.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1661-1666 |
| Number of pages | 6 |
| Journal | Journal of Bone and Mineral Research |
| Volume | 29 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- BONE MINERAL DENSITY
- FRACTURE
- FRACTURE RISK ASSESSMENT TOOL
- OSTEOPOROSIS
- USPSTF OST SCORE FRAX
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Endocrinology, Diabetes and Metabolism
- Medicine(all)
Cite this
Osteoporosis screening in postmenopausal women 50 to 64 years old : Comparison of US preventive services task force strategy and two traditional strategies in the Women's Health Initiative. / Crandall, Carolyn J.; Larson, Joseph; Gourlay, Margaret L.; Donaldson, Meghan G.; LaCroix, Andrea; Cauley, Jane A.; Wactawski-Wende, Jean; Gass, Margery L.; Robbins, John A; Watts, Nelson B.; Ensrud, Kristine E.
In: Journal of Bone and Mineral Research, Vol. 29, No. 7, 2014, p. 1661-1666.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Osteoporosis screening in postmenopausal women 50 to 64 years old
T2 - Comparison of US preventive services task force strategy and two traditional strategies in the Women's Health Initiative
AU - Crandall, Carolyn J.
AU - Larson, Joseph
AU - Gourlay, Margaret L.
AU - Donaldson, Meghan G.
AU - LaCroix, Andrea
AU - Cauley, Jane A.
AU - Wactawski-Wende, Jean
AU - Gass, Margery L.
AU - Robbins, John A
AU - Watts, Nelson B.
AU - Ensrud, Kristine E.
PY - 2014
Y1 - 2014
N2 - The US Preventive Services Task Force (USPSTF) recommends osteoporosis screening for women younger than 65 years whose 10-year predicted risk of major osteoporotic fracture is ≥9.3%. For identifying screening candidates among women aged 50 to 64 years, it is uncertain how the USPSTF strategy compares with the Osteoporosis Self-Assessment Tool (OST) and the Simple Calculated Osteoporosis Risk Estimate (SCORE). We examined data (1994 to 2012) from 5165 Women's Health Initiative participants aged 50 to 64 years. For the USPSTF (Fracture Risk Assessment Tool [FRAX] major fracture risk ≥9.3% calculated without bone mineral density [BMD]), OST (score <2), and SCORE (score >7) strategies, we assessed sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) to discriminate between those with and without femoral neck (FN) T-score ≤-2.5. Sensitivity, specificity, and AUC for identifying FN T-score ≤-2.5 were 34.1%, 85.8%, and 0.60 for USPSTF (FRAX); 74.0%, 70.8%, and 0.72 for SCORE; and 79.8%, 66.3%, and 0.73 for OST. The USPSTF strategy identified about one-third of women aged 50 to 64 years with FN T-scores ≤-2.5. Among women aged 50 to 64 years, the USPSTF strategy was modestly better than chance alone and inferior to conventional SCORE and OST strategies in discriminating between women with and without FN T-score ≤-2.5.
AB - The US Preventive Services Task Force (USPSTF) recommends osteoporosis screening for women younger than 65 years whose 10-year predicted risk of major osteoporotic fracture is ≥9.3%. For identifying screening candidates among women aged 50 to 64 years, it is uncertain how the USPSTF strategy compares with the Osteoporosis Self-Assessment Tool (OST) and the Simple Calculated Osteoporosis Risk Estimate (SCORE). We examined data (1994 to 2012) from 5165 Women's Health Initiative participants aged 50 to 64 years. For the USPSTF (Fracture Risk Assessment Tool [FRAX] major fracture risk ≥9.3% calculated without bone mineral density [BMD]), OST (score <2), and SCORE (score >7) strategies, we assessed sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) to discriminate between those with and without femoral neck (FN) T-score ≤-2.5. Sensitivity, specificity, and AUC for identifying FN T-score ≤-2.5 were 34.1%, 85.8%, and 0.60 for USPSTF (FRAX); 74.0%, 70.8%, and 0.72 for SCORE; and 79.8%, 66.3%, and 0.73 for OST. The USPSTF strategy identified about one-third of women aged 50 to 64 years with FN T-scores ≤-2.5. Among women aged 50 to 64 years, the USPSTF strategy was modestly better than chance alone and inferior to conventional SCORE and OST strategies in discriminating between women with and without FN T-score ≤-2.5.
KW - BONE MINERAL DENSITY
KW - FRACTURE
KW - FRACTURE RISK ASSESSMENT TOOL
KW - OSTEOPOROSIS
KW - USPSTF OST SCORE FRAX
UR - http://www.scopus.com/inward/record.url?scp=84903279971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903279971&partnerID=8YFLogxK
U2 - 10.1002/jbmr.2174
DO - 10.1002/jbmr.2174
M3 - Article
C2 - 24431262
AN - SCOPUS:84903279971
VL - 29
SP - 1661
EP - 1666
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 7
ER -