Osteoporosis screening in postmenopausal women 50 to 64 years old: Comparison of US preventive services task force strategy and two traditional strategies in the Women's Health Initiative

Carolyn J. Crandall, Joseph Larson, Margaret L. Gourlay, Meghan G. Donaldson, Andrea LaCroix, Jane A. Cauley, Jean Wactawski-Wende, Margery L. Gass, John A Robbins, Nelson B. Watts, Kristine E. Ensrud

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The US Preventive Services Task Force (USPSTF) recommends osteoporosis screening for women younger than 65 years whose 10-year predicted risk of major osteoporotic fracture is ≥9.3%. For identifying screening candidates among women aged 50 to 64 years, it is uncertain how the USPSTF strategy compares with the Osteoporosis Self-Assessment Tool (OST) and the Simple Calculated Osteoporosis Risk Estimate (SCORE). We examined data (1994 to 2012) from 5165 Women's Health Initiative participants aged 50 to 64 years. For the USPSTF (Fracture Risk Assessment Tool [FRAX] major fracture risk ≥9.3% calculated without bone mineral density [BMD]), OST (score <2), and SCORE (score >7) strategies, we assessed sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) to discriminate between those with and without femoral neck (FN) T-score ≤-2.5. Sensitivity, specificity, and AUC for identifying FN T-score ≤-2.5 were 34.1%, 85.8%, and 0.60 for USPSTF (FRAX); 74.0%, 70.8%, and 0.72 for SCORE; and 79.8%, 66.3%, and 0.73 for OST. The USPSTF strategy identified about one-third of women aged 50 to 64 years with FN T-scores ≤-2.5. Among women aged 50 to 64 years, the USPSTF strategy was modestly better than chance alone and inferior to conventional SCORE and OST strategies in discriminating between women with and without FN T-score ≤-2.5.

Original languageEnglish (US)
Pages (from-to)1661-1666
Number of pages6
JournalJournal of Bone and Mineral Research
Volume29
Issue number7
DOIs
StatePublished - 2014

Fingerprint

Women's Health
Advisory Committees
Osteoporosis
Femur Neck
Area Under Curve
Sensitivity and Specificity
Osteoporotic Fractures
ROC Curve
Bone Density
Self-Assessment

Keywords

  • BONE MINERAL DENSITY
  • FRACTURE
  • FRACTURE RISK ASSESSMENT TOOL
  • OSTEOPOROSIS
  • USPSTF OST SCORE FRAX

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Osteoporosis screening in postmenopausal women 50 to 64 years old : Comparison of US preventive services task force strategy and two traditional strategies in the Women's Health Initiative. / Crandall, Carolyn J.; Larson, Joseph; Gourlay, Margaret L.; Donaldson, Meghan G.; LaCroix, Andrea; Cauley, Jane A.; Wactawski-Wende, Jean; Gass, Margery L.; Robbins, John A; Watts, Nelson B.; Ensrud, Kristine E.

In: Journal of Bone and Mineral Research, Vol. 29, No. 7, 2014, p. 1661-1666.

Research output: Contribution to journalArticle

Crandall, Carolyn J. ; Larson, Joseph ; Gourlay, Margaret L. ; Donaldson, Meghan G. ; LaCroix, Andrea ; Cauley, Jane A. ; Wactawski-Wende, Jean ; Gass, Margery L. ; Robbins, John A ; Watts, Nelson B. ; Ensrud, Kristine E. / Osteoporosis screening in postmenopausal women 50 to 64 years old : Comparison of US preventive services task force strategy and two traditional strategies in the Women's Health Initiative. In: Journal of Bone and Mineral Research. 2014 ; Vol. 29, No. 7. pp. 1661-1666.
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abstract = "The US Preventive Services Task Force (USPSTF) recommends osteoporosis screening for women younger than 65 years whose 10-year predicted risk of major osteoporotic fracture is ≥9.3{\%}. For identifying screening candidates among women aged 50 to 64 years, it is uncertain how the USPSTF strategy compares with the Osteoporosis Self-Assessment Tool (OST) and the Simple Calculated Osteoporosis Risk Estimate (SCORE). We examined data (1994 to 2012) from 5165 Women's Health Initiative participants aged 50 to 64 years. For the USPSTF (Fracture Risk Assessment Tool [FRAX] major fracture risk ≥9.3{\%} calculated without bone mineral density [BMD]), OST (score <2), and SCORE (score >7) strategies, we assessed sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) to discriminate between those with and without femoral neck (FN) T-score ≤-2.5. Sensitivity, specificity, and AUC for identifying FN T-score ≤-2.5 were 34.1{\%}, 85.8{\%}, and 0.60 for USPSTF (FRAX); 74.0{\%}, 70.8{\%}, and 0.72 for SCORE; and 79.8{\%}, 66.3{\%}, and 0.73 for OST. The USPSTF strategy identified about one-third of women aged 50 to 64 years with FN T-scores ≤-2.5. Among women aged 50 to 64 years, the USPSTF strategy was modestly better than chance alone and inferior to conventional SCORE and OST strategies in discriminating between women with and without FN T-score ≤-2.5.",
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