Osteoporosis associated with rheumatologic disorders

Alanna M.K. Dubrovsky, Steven R. Goldring, Nancy E. Lane

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The systemic and focal joint inflammation that characterizes many of the rheumatologic disorders can also be accompanied by adverse effects on the skeleton. Much of the attention has focused on the focal bone resorption in articular and periarticular bone associated with disorders such as rheumatoid arthritis (RA), the prototypical inflammatory joint disease. However, it is clear that many of the inflammatory rheumatic disorders also have effects on systemic bone remodeling. Studies have documented that osteoporosis and increased risk of fracture account for a component of the morbidity associated with these conditions. In part, these adverse skeletal effects may be related to the therapies used to treat these diseases. This review will focus on the inflammatory rheumatologic disorders that target the articular and periarticular tissues. These entities include RA, juvenile idiopathic arthritis (previously classified as juvenile RA), the seronegative spondyloarthropathies, and systemic lupus erythematosus. It is important to note, however, that many of the related immune-mediated rheumatic conditions such as systemic vasculitis may also be accompanied by adverse effects on skeletal remodeling and increased risk for osteoporosis, in part, related to the use of high-dose glucocorticoids and other therapies that adversely affect the skeleton.

Original languageEnglish (US)
Title of host publicationMarcus and Feldman’s Osteoporosis
PublisherElsevier
Pages1309-1324
Number of pages16
ISBN (Electronic)9780128130735
DOIs
StatePublished - Jan 1 2020

Keywords

  • bone loss
  • Juvenile idiopathic arthritis (JIA)
  • RANKL
  • Rheumatoid arthritis (RA)
  • Rheumatologic disorders
  • Seronegative spondyloarthropathies
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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