Osteonecrosis of the jaws in dogs in previously irradiated fields: 13 cases (1989-2014)

Ana Nemec, Boaz Arzi, Katherine S Hansen, Brian G Murphy, Milinda J. Lommer, Santiago Peralta, Frank J Verstraete

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this report was to characterize osteonecrosis of the jaws (ONJ) in previously irradiated fields in dogs that underwent radiotherapy (RT) for oral tumors. Osteoradionecrosis of the jaw (ORNJ) was further defined as osteonecrosis in a previously irradiated field in the absence of a tumor. Thirteen dogs clinically diagnosed with 15 ONJ lesions were included in this retrospective case series. Medical records were reviewed for: breed, sex, weight, and age of the patient, tumor type, location in the oral cavity and size, location of the ONJ, time from RT to ONJ onset, known duration of the ONJ, and tumor presence. Where available, histological assessment of tissues obtained from the primary tumor, and tissues obtained from the ONJ lesion, was performed, and computed tomographic (CT) images and dental radiographs were reviewed. RT and other treatment details were also reviewed. Twelve dogs developed ONJ in the area of the previously irradiated tumor or the jaw closest to the irradiated mucosal tumor. Recurrence of neoplasia was evident at the time of ONJ diagnosis in five dogs. Time from RT start to ONJ onset varied from 2 to 44 months. In three cases, ORNJ developed after dental extractions in the irradiated field. Dental radiographs mostly revealed a moth-eaten pattern of bone loss, CT mostly revealed osteolysis, and histopathology was consistent with osteonecrosis. To conclude, development of ONJ/ORNJ following RT is a rare, but potentially fatal complication. Patients undergoing RT may benefit from a comprehensive oral and dental examination and treatment prior to RT.

Original languageEnglish (US)
Article number5
JournalFrontiers in Veterinary Science
Volume2
Issue numberAPR
DOIs
StatePublished - Apr 1 2015

Fingerprint

Osteonecrosis
Jaw
jaws
Dogs
dogs
radiotherapy
Radiotherapy
neoplasms
Osteoradionecrosis
Neoplasms
teeth
mouth
Tooth
lesions (animal)
Oral Diagnosis
Tooth Extraction
Osteolysis
Moths
histopathology
Medical Records

Keywords

  • Dog
  • Jaw osteonecrosis
  • Oral tumors
  • Osteoradionecrosis
  • Radiotherapy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Osteonecrosis of the jaws in dogs in previously irradiated fields : 13 cases (1989-2014). / Nemec, Ana; Arzi, Boaz; Hansen, Katherine S; Murphy, Brian G; Lommer, Milinda J.; Peralta, Santiago; Verstraete, Frank J.

In: Frontiers in Veterinary Science, Vol. 2, No. APR, 5, 01.04.2015.

Research output: Contribution to journalArticle

@article{39f90db3426f4443975c8fd332e6c78d,
title = "Osteonecrosis of the jaws in dogs in previously irradiated fields: 13 cases (1989-2014)",
abstract = "The aim of this report was to characterize osteonecrosis of the jaws (ONJ) in previously irradiated fields in dogs that underwent radiotherapy (RT) for oral tumors. Osteoradionecrosis of the jaw (ORNJ) was further defined as osteonecrosis in a previously irradiated field in the absence of a tumor. Thirteen dogs clinically diagnosed with 15 ONJ lesions were included in this retrospective case series. Medical records were reviewed for: breed, sex, weight, and age of the patient, tumor type, location in the oral cavity and size, location of the ONJ, time from RT to ONJ onset, known duration of the ONJ, and tumor presence. Where available, histological assessment of tissues obtained from the primary tumor, and tissues obtained from the ONJ lesion, was performed, and computed tomographic (CT) images and dental radiographs were reviewed. RT and other treatment details were also reviewed. Twelve dogs developed ONJ in the area of the previously irradiated tumor or the jaw closest to the irradiated mucosal tumor. Recurrence of neoplasia was evident at the time of ONJ diagnosis in five dogs. Time from RT start to ONJ onset varied from 2 to 44 months. In three cases, ORNJ developed after dental extractions in the irradiated field. Dental radiographs mostly revealed a moth-eaten pattern of bone loss, CT mostly revealed osteolysis, and histopathology was consistent with osteonecrosis. To conclude, development of ONJ/ORNJ following RT is a rare, but potentially fatal complication. Patients undergoing RT may benefit from a comprehensive oral and dental examination and treatment prior to RT.",
keywords = "Dog, Jaw osteonecrosis, Oral tumors, Osteoradionecrosis, Radiotherapy",
author = "Ana Nemec and Boaz Arzi and Hansen, {Katherine S} and Murphy, {Brian G} and Lommer, {Milinda J.} and Santiago Peralta and Verstraete, {Frank J}",
year = "2015",
month = "4",
day = "1",
doi = "10.3389/fvets.2015.00005",
language = "English (US)",
volume = "2",
journal = "Frontiers in Veterinary Science",
issn = "2297-1769",
publisher = "Frontiers Media S. A.",
number = "APR",

}

TY - JOUR

T1 - Osteonecrosis of the jaws in dogs in previously irradiated fields

T2 - 13 cases (1989-2014)

AU - Nemec, Ana

AU - Arzi, Boaz

AU - Hansen, Katherine S

AU - Murphy, Brian G

AU - Lommer, Milinda J.

AU - Peralta, Santiago

AU - Verstraete, Frank J

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The aim of this report was to characterize osteonecrosis of the jaws (ONJ) in previously irradiated fields in dogs that underwent radiotherapy (RT) for oral tumors. Osteoradionecrosis of the jaw (ORNJ) was further defined as osteonecrosis in a previously irradiated field in the absence of a tumor. Thirteen dogs clinically diagnosed with 15 ONJ lesions were included in this retrospective case series. Medical records were reviewed for: breed, sex, weight, and age of the patient, tumor type, location in the oral cavity and size, location of the ONJ, time from RT to ONJ onset, known duration of the ONJ, and tumor presence. Where available, histological assessment of tissues obtained from the primary tumor, and tissues obtained from the ONJ lesion, was performed, and computed tomographic (CT) images and dental radiographs were reviewed. RT and other treatment details were also reviewed. Twelve dogs developed ONJ in the area of the previously irradiated tumor or the jaw closest to the irradiated mucosal tumor. Recurrence of neoplasia was evident at the time of ONJ diagnosis in five dogs. Time from RT start to ONJ onset varied from 2 to 44 months. In three cases, ORNJ developed after dental extractions in the irradiated field. Dental radiographs mostly revealed a moth-eaten pattern of bone loss, CT mostly revealed osteolysis, and histopathology was consistent with osteonecrosis. To conclude, development of ONJ/ORNJ following RT is a rare, but potentially fatal complication. Patients undergoing RT may benefit from a comprehensive oral and dental examination and treatment prior to RT.

AB - The aim of this report was to characterize osteonecrosis of the jaws (ONJ) in previously irradiated fields in dogs that underwent radiotherapy (RT) for oral tumors. Osteoradionecrosis of the jaw (ORNJ) was further defined as osteonecrosis in a previously irradiated field in the absence of a tumor. Thirteen dogs clinically diagnosed with 15 ONJ lesions were included in this retrospective case series. Medical records were reviewed for: breed, sex, weight, and age of the patient, tumor type, location in the oral cavity and size, location of the ONJ, time from RT to ONJ onset, known duration of the ONJ, and tumor presence. Where available, histological assessment of tissues obtained from the primary tumor, and tissues obtained from the ONJ lesion, was performed, and computed tomographic (CT) images and dental radiographs were reviewed. RT and other treatment details were also reviewed. Twelve dogs developed ONJ in the area of the previously irradiated tumor or the jaw closest to the irradiated mucosal tumor. Recurrence of neoplasia was evident at the time of ONJ diagnosis in five dogs. Time from RT start to ONJ onset varied from 2 to 44 months. In three cases, ORNJ developed after dental extractions in the irradiated field. Dental radiographs mostly revealed a moth-eaten pattern of bone loss, CT mostly revealed osteolysis, and histopathology was consistent with osteonecrosis. To conclude, development of ONJ/ORNJ following RT is a rare, but potentially fatal complication. Patients undergoing RT may benefit from a comprehensive oral and dental examination and treatment prior to RT.

KW - Dog

KW - Jaw osteonecrosis

KW - Oral tumors

KW - Osteoradionecrosis

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85039559831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039559831&partnerID=8YFLogxK

U2 - 10.3389/fvets.2015.00005

DO - 10.3389/fvets.2015.00005

M3 - Article

AN - SCOPUS:85039559831

VL - 2

JO - Frontiers in Veterinary Science

JF - Frontiers in Veterinary Science

SN - 2297-1769

IS - APR

M1 - 5

ER -