Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons

Pamela J Lein, Mary Johnson, Xin Guo, David Rueger, Dennis Higgins

Research output: Contribution to journalArticle

214 Scopus citations

Abstract

Sympathetic neurons from perinatal rat pups extend only a single axon when maintained in culture in the absence of glia and serum. Exposure to recombinant osteogenic protein-1 (OP-1) selectively induces the formation of dendrites that correctly segregate and modify cytoskeletal and membrane proteins and form synaptic contacts of appropriate polarity. OP-1 requires nerve growth factor (NGF) as a cofactor, and, in the presence of optimal concentrations of NGF, OP1-induced dendritic growth from cultured perinatal neurons is comparable to that observed in situ. Sympathetic neuroblasts that had not formed dendrites in situ also responded to OP-1 in culture, indicating that OP-1 can cause de novo formation as well as regeneration of dendrites. These data imply that specific signals can regulate the development of neuronal shape and polarity.

Original languageEnglish (US)
Pages (from-to)597-605
Number of pages9
JournalNeuron
Volume15
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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