Osteogenic benefits of low-intensity pulsed ultrasound and vibration in a rodent osseointegration model

David S. Ruppert, Ola L.A. Harrysson, Denis J. Marcellin-Little, Seth Bollenbecker, Paul S. Weinhold

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: Osseointegrated prostheses are increasingly used for amputees, however, the lengthy rehabilitation time of these prostheses remains a challenge to their implementation. The aim of this study was to investigate the ability of locally applied vibration or low-intensity pulsed ultrasound (LIPUS) to accelerate osseointegration and increase peri-implant bone volume. Methods: A 4-week and 8-week rodent study were conducted in a femoral intramedullary implant model (control, vibration, LIPUS, and combined treatment) to determine effects on healing. Osseointegration was evaluated quantitatively through mechanical, µCT and histological evaluations. Results: Maximum pushout load at 4 weeks increased with LIPUS relative to control (37.7%, P=0.002). Histologically, LIPUS and vibration separately increased peri-implant bone formation after 4 weeks relative to control. Vibration resulted in greater peri-implant bone after 8 weeks than all other groups (25.7%, P<0.001) However, no significant group differences in pushout load were noted at 8 weeks. Conclusions: Although vibration increased bone around implants, LIPUS was superior to vibration for accelerating osseointegration and increasing bone-implant failure loads at 4 weeks. However, the LIPUS benefits on osseointegration at 4 weeks were not sustained at 8 weeks.

Original languageEnglish (US)
Pages (from-to)150-158
Number of pages9
JournalJournal of Musculoskeletal Neuronal Interactions
Issue number2
StatePublished - Jun 1 2019
Externally publishedYes


  • Bone-Implant Interface
  • Intramedullary Implant
  • Low-Intensity Pulsed Ultrasound
  • Osseointegration
  • Vibration

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine


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