Osteobiologic agents in spine surgery

Vivek Mohan, Munish C. Gupta

Research output: Chapter in Book/Report/Conference proceedingChapter


The treatment of spinal disorders has evolved greatly over the last 30. years, with developments in instrumentation and biologics. Pedicle screw technology has improved fusion rates. However, even with these advances the dilemma of non-unions in spinal surgery still exists. Patients with challenging deformities or biology continue to have high rates of non-unions and autograft harvest carries its own set of complications. With the current plethora of biologics available for use, every spine surgeon should understand bone biology and the utility of each product for the benefit of their patients. In this chapter, we will discuss the biology of spinal fusions and detail each major category of biological products, from autograft to ceramics, while detailing their indications and known complications.

Original languageEnglish (US)
Title of host publicationBiomaterials for Spinal Surgery
PublisherElsevier Ltd
Number of pages29
ISBN (Print)9781845699864
StatePublished - Mar 2012


  • Allograft
  • Autograft
  • Bone formation
  • Bone morphogenic protein
  • Cellular concentrates
  • Ceramics
  • Spinal fusion
  • Stem cells

ASJC Scopus subject areas

  • Materials Science(all)


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