Osteoarthritis: New insights - Part 1: The disease and its risk factors

D. T. Felson, R. C. Lawrence, P. A. Dieppe, R. Hirsch, C. G. Helmick, J. M. Jordan, R. S. Kington, Nancy E Lane, M. C. Nevitt, Y. Zhang, M. Sowers, T. McAlindon, T. D. Spector, A. R. Poole, S. Z. Yanovski, G. Ateshian, L. Sharma, J. A. Buckwalter, K. D. Brandt, J. F. Fries

Research output: Contribution to journalArticle

1601 Scopus citations

Abstract

Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States. It is a complex disease whose etiology bridges biomechanics and biochemistry. Evidence is growing for the role of systemic factors (such as genetics, dietary intake, estrogen use, and bone density) and of local biomechanical factors (such as muscle weakness, obesity, and joint laxity). These risk factors are particularly important in weight-bearing joints, and modifying them may present opportunities for prevention of osteoarthritis-related pain and disability. Major advances in management to reduce pain and disability are yielding a panoply of available treatments ranging from nutriceuticals to chondrocyte transplantation, new oral anti-inflammatory medications, and health education. This article is part 1 of a two-part summary of a National Institutes of Health conference. The conference brought together experts on osteoarthritis from diverse backgrounds and provided a multidisciplinary and comprehensive summary of recent advances in the prevention of osteoarthritis onset, progression, and disability. Part 1 focuses on a new understanding of what osteoarthritis is and on risk factors that predispose to disease occurrence. It concludes with a discussion of the impact of osteoarthritis on disability.

Original languageEnglish (US)
Pages (from-to)635-646
Number of pages12
JournalAnnals of Internal Medicine
Volume133
Issue number8
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Osteoarthritis: New insights - Part 1: The disease and its risk factors'. Together they form a unique fingerprint.

  • Cite this

    Felson, D. T., Lawrence, R. C., Dieppe, P. A., Hirsch, R., Helmick, C. G., Jordan, J. M., Kington, R. S., Lane, N. E., Nevitt, M. C., Zhang, Y., Sowers, M., McAlindon, T., Spector, T. D., Poole, A. R., Yanovski, S. Z., Ateshian, G., Sharma, L., Buckwalter, J. A., Brandt, K. D., & Fries, J. F. (2000). Osteoarthritis: New insights - Part 1: The disease and its risk factors. Annals of Internal Medicine, 133(8), 635-646.