Osmotic reflexion coefficients of capillary walls to low molecular weight hydrophylic solutes measured in single perfused capillaries of the frog mesentery

F. E. Curry, J. C. Mason, C. C. Michel

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Individual capillaries of the transilluminated frog mesentery have been perfused with suspensions of human red cells in frog Ringer solution containing 1.0 g albumin 100 ml-1. The outer surface of the mesentery has been washed with normal frog Ringer solution and with frog Ringer solutions made hypertonic by addition of one of the following solutes: sodium chloride (100 mmole/l); urea (100 mmole/l); sucrose (20-50 mmole/l); cyanocobalamin (8.5 mmole/l). The temperature of the mesentery was between 14 and 16° in all experiments. The data suggest the exclusive water channel represents about 10% of the total filtration coefficient in frog mesenteric capillaries. The shared channel shows relatively little restriction to the molecules investigated. Estimates of the volume flow through the two channels are made for conditions where hydrostatic pressure differences and osmotic pressure differences are the driving forces.

Original languageEnglish (US)
Pages (from-to)319-336
Number of pages18
JournalJournal of Physiology
Volume261
Issue number2
StatePublished - 1976
Externally publishedYes

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Mesentery
Anura
Molecular Weight
Aquaporins
Hydrostatic Pressure
Osmotic Pressure
Vitamin B 12
Sodium Chloride
Sucrose
Urea
Albumins
Suspensions
Temperature
Ringer's solution

ASJC Scopus subject areas

  • Physiology

Cite this

Osmotic reflexion coefficients of capillary walls to low molecular weight hydrophylic solutes measured in single perfused capillaries of the frog mesentery. / Curry, F. E.; Mason, J. C.; Michel, C. C.

In: Journal of Physiology, Vol. 261, No. 2, 1976, p. 319-336.

Research output: Contribution to journalArticle

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