Individual capillaries of the transilluminated frog mesentery have been perfused with suspensions of human red cells in frog Ringer solution containing 1.0 g albumin 100 ml-1. The outer surface of the mesentery has been washed with normal frog Ringer solution and with frog Ringer solutions made hypertonic by addition of one of the following solutes: sodium chloride (100 mmole/l); urea (100 mmole/l); sucrose (20-50 mmole/l); cyanocobalamin (8.5 mmole/l). The temperature of the mesentery was between 14 and 16° in all experiments. The data suggest the exclusive water channel represents about 10% of the total filtration coefficient in frog mesenteric capillaries. The shared channel shows relatively little restriction to the molecules investigated. Estimates of the volume flow through the two channels are made for conditions where hydrostatic pressure differences and osmotic pressure differences are the driving forces.
|Original language||English (US)|
|Number of pages||18|
|Journal||Journal of Physiology|
|State||Published - 1976|
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