Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts

Jun You, Marnie M. Saunders, Clare E Yellowley-genetos, Henry J. Donahue, Christopher R. Jacobs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effects of oscillatory flow on the synthesis of prostaglandin E 2 (PGE 2) and cyclooxygenase-2 (Cox-2) mRNA levels were investigated. The goal was to elucidate the oscillatory flow-induced PGE 2 signal pathway in bone cells. The results showed that oscillating flow doubled the production of PGE 2, while elevating Cox-2 mRNA levels by 410% for the control case.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
EditorsR.D. Kamm, G.W. Schmid-Schoenbein, G.A. Atesian, M.S. Hefzy
Pages163-164
Number of pages2
Volume50
StatePublished - 2001
Externally publishedYes
EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States
Duration: Jun 27 2001Jul 1 2001

Other

OtherProceedings of the 2001 Bioengineering Conference
CountryUnited States
CitySnowbird, UT
Period6/27/017/1/01

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    You, J., Saunders, M. M., Yellowley-genetos, C. E., Donahue, H. J., & Jacobs, C. R. (2001). Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts. In R. D. Kamm, G. W. Schmid-Schoenbein, G. A. Atesian, & M. S. Hefzy (Eds.), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 50, pp. 163-164)