Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts

Jun You; Marnie M. Saunders; Clare E Yellowley-genetos; Henry J. Donahue; Christopher R. Jacobs

Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts

Jun You, Marnie M. Saunders, Clare E Yellowley-genetos, Henry J. Donahue, Christopher R. Jacobs

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The effects of oscillatory flow on the synthesis of prostaglandin E ₂ (PGE ₂) and cyclooxygenase-2 (Cox-2) mRNA levels were investigated. The goal was to elucidate the oscillatory flow-induced PGE ₂ signal pathway in bone cells. The results showed that oscillating flow doubled the production of PGE ₂, while elevating Cox-2 mRNA levels by 410% for the control case.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Editors	R.D. Kamm, G.W. Schmid-Schoenbein, G.A. Atesian, M.S. Hefzy
Pages	163-164
Number of pages	2
Volume	50
State	Published - 2001
Externally published	Yes
Event	Proceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States Duration: Jun 27 2001 → Jul 1 2001

Other

Other	Proceedings of the 2001 Bioengineering Conference
Country	United States
City	Snowbird, UT
Period	6/27/01 → 7/1/01

ASJC Scopus subject areas

Engineering(all)

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You, J., Saunders, M. M., Yellowley-genetos, C. E., Donahue, H. J., & Jacobs, C. R. (2001). Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts. In R. D. Kamm, G. W. Schmid-Schoenbein, G. A. Atesian, & M. S. Hefzy (Eds.), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 50, pp. 163-164)

Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts. / You, Jun; Saunders, Marnie M.; Yellowley-genetos, Clare E; Donahue, Henry J.; Jacobs, Christopher R.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. ed. / R.D. Kamm; G.W. Schmid-Schoenbein; G.A. Atesian; M.S. Hefzy. Vol. 50 2001. p. 163-164.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

You, J, Saunders, MM, Yellowley-genetos, CE, Donahue, HJ & Jacobs, CR 2001, Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts. in RD Kamm, GW Schmid-Schoenbein, GA Atesian & MS Hefzy (eds), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 50, pp. 163-164, Proceedings of the 2001 Bioengineering Conference, Snowbird, UT, United States, 6/27/01.

You, Jun ; Saunders, Marnie M. ; Yellowley-genetos, Clare E ; Donahue, Henry J. ; Jacobs, Christopher R. / Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. editor / R.D. Kamm ; G.W. Schmid-Schoenbein ; G.A. Atesian ; M.S. Hefzy. Vol. 50 2001. pp. 163-164

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AB - The effects of oscillatory flow on the synthesis of prostaglandin E 2 (PGE 2) and cyclooxygenase-2 (Cox-2) mRNA levels were investigated. The goal was to elucidate the oscillatory flow-induced PGE 2 signal pathway in bone cells. The results showed that oscillating flow doubled the production of PGE 2, while elevating Cox-2 mRNA levels by 410% for the control case.

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Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts

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