Abstract
The effects of oscillatory flow on the synthesis of prostaglandin E 2 (PGE 2) and cyclooxygenase-2 (Cox-2) mRNA levels were investigated. The goal was to elucidate the oscillatory flow-induced PGE 2 signal pathway in bone cells. The results showed that oscillating flow doubled the production of PGE 2, while elevating Cox-2 mRNA levels by 410% for the control case.
| Original language | English (US) |
|---|---|
| Title of host publication | American Society of Mechanical Engineers, Bioengineering Division (Publication) BED |
| Editors | R.D. Kamm, G.W. Schmid-Schoenbein, G.A. Atesian, M.S. Hefzy |
| Pages | 163-164 |
| Number of pages | 2 |
| Volume | 50 |
| State | Published - 2001 |
| Externally published | Yes |
| Event | Proceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States Duration: Jun 27 2001 → Jul 1 2001 |
Other
| Other | Proceedings of the 2001 Bioengineering Conference |
|---|---|
| Country | United States |
| City | Snowbird, UT |
| Period | 6/27/01 → 7/1/01 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts. / You, Jun; Saunders, Marnie M.; Yellowley-genetos, Clare E; Donahue, Henry J.; Jacobs, Christopher R.
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. ed. / R.D. Kamm; G.W. Schmid-Schoenbein; G.A. Atesian; M.S. Hefzy. Vol. 50 2001. p. 163-164.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts
AU - You, Jun
AU - Saunders, Marnie M.
AU - Yellowley-genetos, Clare E
AU - Donahue, Henry J.
AU - Jacobs, Christopher R.
PY - 2001
Y1 - 2001
N2 - The effects of oscillatory flow on the synthesis of prostaglandin E 2 (PGE 2) and cyclooxygenase-2 (Cox-2) mRNA levels were investigated. The goal was to elucidate the oscillatory flow-induced PGE 2 signal pathway in bone cells. The results showed that oscillating flow doubled the production of PGE 2, while elevating Cox-2 mRNA levels by 410% for the control case.
AB - The effects of oscillatory flow on the synthesis of prostaglandin E 2 (PGE 2) and cyclooxygenase-2 (Cox-2) mRNA levels were investigated. The goal was to elucidate the oscillatory flow-induced PGE 2 signal pathway in bone cells. The results showed that oscillating flow doubled the production of PGE 2, while elevating Cox-2 mRNA levels by 410% for the control case.
UR - http://www.scopus.com/inward/record.url?scp=0242441687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242441687&partnerID=8YFLogxK
M3 - Conference contribution
VL - 50
SP - 163
EP - 164
BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
A2 - Kamm, R.D.
A2 - Schmid-Schoenbein, G.W.
A2 - Atesian, G.A.
A2 - Hefzy, M.S.
ER -