Abstract
Low-frequency (delta/theta band) hippocampal neural oscillations play prominent roles in computational models of spatial navigation, but their exact function remains unknown. Some theories propose they are primarily generated in response to sensorimotor processing, while others suggest a role in memory-related processing. We directly recorded hippocampal EEG activity in patients undergoing seizure monitoring while they explored a virtual environment containing teleporters. Critically, this manipulation allowed patients to experience movement through space in the absence of visual and self-motion cues. The prevalence and duration of low-frequency hippocampal oscillations were unchanged by this manipulation, indicating that sensorimotor processing was not required to elicit them during navigation. Furthermore, the frequency-wise pattern of oscillation prevalence during teleportation contained spatial information capable of classifying the distance teleported. These results demonstrate that movement-related sensory information is not required to drive spatially informative low-frequency hippocampal oscillations during navigation and suggest a specific function in memory-related spatial updating.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1180-1186 |
| Number of pages | 7 |
| Journal | Neuron |
| Volume | 89 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 16 2016 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
Cite this
Oscillations Go the Distance : Low-Frequency Human Hippocampal Oscillations Code Spatial Distance in the Absence of Sensory Cues during Teleportation. / Vass, Lindsay K.; Copara, Milagros S.; Seyal, Masud; Shahlaie, Kiarash; Tomaszewski Farias, Sarah E; Shen, Peter Y; Ekstrom, Arne D.
In: Neuron, Vol. 89, No. 6, 16.03.2016, p. 1180-1186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oscillations Go the Distance
T2 - Low-Frequency Human Hippocampal Oscillations Code Spatial Distance in the Absence of Sensory Cues during Teleportation
AU - Vass, Lindsay K.
AU - Copara, Milagros S.
AU - Seyal, Masud
AU - Shahlaie, Kiarash
AU - Tomaszewski Farias, Sarah E
AU - Shen, Peter Y
AU - Ekstrom, Arne D.
PY - 2016/3/16
Y1 - 2016/3/16
N2 - Low-frequency (delta/theta band) hippocampal neural oscillations play prominent roles in computational models of spatial navigation, but their exact function remains unknown. Some theories propose they are primarily generated in response to sensorimotor processing, while others suggest a role in memory-related processing. We directly recorded hippocampal EEG activity in patients undergoing seizure monitoring while they explored a virtual environment containing teleporters. Critically, this manipulation allowed patients to experience movement through space in the absence of visual and self-motion cues. The prevalence and duration of low-frequency hippocampal oscillations were unchanged by this manipulation, indicating that sensorimotor processing was not required to elicit them during navigation. Furthermore, the frequency-wise pattern of oscillation prevalence during teleportation contained spatial information capable of classifying the distance teleported. These results demonstrate that movement-related sensory information is not required to drive spatially informative low-frequency hippocampal oscillations during navigation and suggest a specific function in memory-related spatial updating.
AB - Low-frequency (delta/theta band) hippocampal neural oscillations play prominent roles in computational models of spatial navigation, but their exact function remains unknown. Some theories propose they are primarily generated in response to sensorimotor processing, while others suggest a role in memory-related processing. We directly recorded hippocampal EEG activity in patients undergoing seizure monitoring while they explored a virtual environment containing teleporters. Critically, this manipulation allowed patients to experience movement through space in the absence of visual and self-motion cues. The prevalence and duration of low-frequency hippocampal oscillations were unchanged by this manipulation, indicating that sensorimotor processing was not required to elicit them during navigation. Furthermore, the frequency-wise pattern of oscillation prevalence during teleportation contained spatial information capable of classifying the distance teleported. These results demonstrate that movement-related sensory information is not required to drive spatially informative low-frequency hippocampal oscillations during navigation and suggest a specific function in memory-related spatial updating.
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U2 - 10.1016/j.neuron.2016.01.045
DO - 10.1016/j.neuron.2016.01.045
M3 - Article
C2 - 26924436
AN - SCOPUS:84960806062
VL - 89
SP - 1180
EP - 1186
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 6
ER -