Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells

Dhrubajyoti Chakravarti, Muhammad Zahid, Matthew Backora, Erin M. Myers, Nilesh Gaikwad, Dennis D. Weisenburger, Ercole L. Cavalieri, Eleanor G. Rogan, Shantaram S. Joshi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Benzene is a known leukemogen. It has been hypothesized that benzene and natural estrogens initiate cancer by forming ortho-quinones (catechol quinones) that react with DNA in cells. These quinones form depurinating DNA adducts that generate the mutations leading to cancer. This study examined whether the treatment of normal human peripheral blood mononuclear cells with the ortho-quinones of benzene or estradiol would form DNA adducts and elicit an alteration in the proliferation of these cells. Both estradiol-3,4-quinone and benzene ortho-quinone formed depurinating DNA adducts and significantly increased the mitogen-induced proliferation of normal blood mononuclear cells. Immunophenotyping of the estradiol-3,4-quinone-treated blood cells indicated that monocyte/ macrophage, natural killer and T-cells were particularly prone to hyperproliferation. Thus, DNA damage induced by the ortho-quinones of benzene and estradiol may promote the growth of human blood mononuclear cells, including those that appear in large numbers in leukemia and lymphoma.

Original languageEnglish (US)
Pages (from-to)2635-2644
Number of pages10
JournalLeukemia and Lymphoma
Volume47
Issue number12
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Quinones
Benzene
Blood Cells
Estrogens
DNA Adducts
Estradiol
Immunophenotyping
Natural Killer T-Cells
Mitogens
DNA Damage
Monocytes
Lymphoma
Neoplasms
Leukemia
Macrophages
Cell Proliferation
Mutation
DNA
Growth

Keywords

  • Benzene
  • Estrogen
  • Leukemia
  • Quinone

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Chakravarti, D., Zahid, M., Backora, M., Myers, E. M., Gaikwad, N., Weisenburger, D. D., ... Joshi, S. S. (2006). Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells. Leukemia and Lymphoma, 47(12), 2635-2644. https://doi.org/10.1080/10428190600931937

Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells. / Chakravarti, Dhrubajyoti; Zahid, Muhammad; Backora, Matthew; Myers, Erin M.; Gaikwad, Nilesh; Weisenburger, Dennis D.; Cavalieri, Ercole L.; Rogan, Eleanor G.; Joshi, Shantaram S.

In: Leukemia and Lymphoma, Vol. 47, No. 12, 12.2006, p. 2635-2644.

Research output: Contribution to journalArticle

Chakravarti, D, Zahid, M, Backora, M, Myers, EM, Gaikwad, N, Weisenburger, DD, Cavalieri, EL, Rogan, EG & Joshi, SS 2006, 'Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells', Leukemia and Lymphoma, vol. 47, no. 12, pp. 2635-2644. https://doi.org/10.1080/10428190600931937
Chakravarti, Dhrubajyoti ; Zahid, Muhammad ; Backora, Matthew ; Myers, Erin M. ; Gaikwad, Nilesh ; Weisenburger, Dennis D. ; Cavalieri, Ercole L. ; Rogan, Eleanor G. ; Joshi, Shantaram S. / Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells. In: Leukemia and Lymphoma. 2006 ; Vol. 47, No. 12. pp. 2635-2644.
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