Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE

Monica Moreno, Fuzheng Guo, Emily Mills Ko, Peter Bannerman, Athena Soulika, David E Pleasure

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive immunity, and have been hypothesized to play an important role in multiple sclerosis progression. Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 provides a means by which to explore the genesis and disease significance of astrogliosis during a chronic immune-mediated CNS inflammatory/demyelinative disorder that, in its' pathological features, strongly resembles multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalJournal of the Neurological Sciences
Volume333
Issue number1-2
DOIs
StatePublished - Oct 15 2013

Keywords

  • Astroglia
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE'. Together they form a unique fingerprint.

  • Cite this