Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE

Monica Moreno, Fuzheng Guo, Emily Mills Ko, Peter Bannerman, Athena Soulika, David E Pleasure

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive immunity, and have been hypothesized to play an important role in multiple sclerosis progression. Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 provides a means by which to explore the genesis and disease significance of astrogliosis during a chronic immune-mediated CNS inflammatory/demyelinative disorder that, in its' pathological features, strongly resembles multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalJournal of the Neurological Sciences
Volume333
Issue number1-2
DOIs
StatePublished - Oct 15 2013

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Multiple Sclerosis
Peptides
Autoimmune Experimental Encephalomyelitis
Adaptive Immunity
Innate Immunity
Astrocytes
Immunization
myelin oligodendrocyte glycoprotein (35-55)

Keywords

  • Astroglia
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. / Moreno, Monica; Guo, Fuzheng; Ko, Emily Mills; Bannerman, Peter; Soulika, Athena; Pleasure, David E.

In: Journal of the Neurological Sciences, Vol. 333, No. 1-2, 15.10.2013, p. 55-59.

Research output: Contribution to journalArticle

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