Organochlorine contaminant exposure and associations with hematological and humoral immune functional assays with dam age as a factor in free-ranging northern fur seal pups (Callorhinus ursinus)

Kimberlee B. Beckmen, John E. Blake, Gina M. Ylitalo, Jeffrey L Stott, Todd M. O'Hara

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64 Citations (Scopus)

Abstract

Potential effects of organochlorine contaminant (OC) exposure on humoral immune function and health of free-ranging northern fur seals were investigated. Forty-two "neonates" were captured for blood sample collection and re-sampled as "pups" 29-51 days later. OCs were extracted from whole blood to identify polychlorinated biphenyl congeners and chlorinated pesticides by high performance liquid chromatography. Humoral immune function was assessed by antibody responses to vaccination and immunoglobulin concentrations. Additional health status indicators included leukocyte counts and haptoglobin concentrations. Mean OC concentrations were higher in neonates than at recapture. Neonates of young dams had higher mean OC concentrations than neonates of older dams. A higher proportion of old dam's pups developed a twofold or greater increase in antigen-specific antibodies compared to young dam's pups. Higher OC exposure and poor immune responses in first-born pups may indicate a higher risk of secondary morbidity and mortality than pups of multiparous dams.

Original languageEnglish (US)
Pages (from-to)594-606
Number of pages13
JournalMarine Pollution Bulletin
Volume46
Issue number5
DOIs
StatePublished - May 2003

Fingerprint

Callorhinus
organochlorine
seals
pups
fur
Dams
neonate
Assays
dam
assay
Impurities
neonates
pollutant
assays
Antibodies
antibody
Blood
blood
Health
antibodies

Keywords

  • Haptoglobin
  • Humoral immunity
  • Immunoglobulins
  • Organochlorine contaminants
  • Polychlorinated biphenyls
  • Tetanus toxoid

ASJC Scopus subject areas

  • Aquatic Science
  • Oceanography
  • Pollution

Cite this

Organochlorine contaminant exposure and associations with hematological and humoral immune functional assays with dam age as a factor in free-ranging northern fur seal pups (Callorhinus ursinus). / Beckmen, Kimberlee B.; Blake, John E.; Ylitalo, Gina M.; Stott, Jeffrey L; O'Hara, Todd M.

In: Marine Pollution Bulletin, Vol. 46, No. 5, 05.2003, p. 594-606.

Research output: Contribution to journalArticle

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