Organization and function of the cytoskeleton in polarized epithelial cells

a component of the protein sorting machinery

Robert W. Mays, Kenneth A Beck, W. James Nelson

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Development and maintenance of cell-surface polarity in epithelial cells requires specialized localization of proteins to functionally and structuraally distinct plasma membrane domains. The organization of these domains is dependent upon targeted delivery of transport vesicles between different membrane compartments, and upon protein sorting in the membranes of the Golgi complex and cell surface. Increasing evidence has been gathered in recent years that cytoskeletal components facilitate these processes.

Original languageEnglish (US)
Pages (from-to)16-24
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume6
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Protein Transport
Cellular Structures
Cytoskeleton
Epithelial Cells
Transport Vesicles
Cell Polarity
Membranes
Golgi Apparatus
Maintenance
Cell Membrane
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Organization and function of the cytoskeleton in polarized epithelial cells : a component of the protein sorting machinery. / Mays, Robert W.; Beck, Kenneth A; James Nelson, W.

In: Current Opinion in Cell Biology, Vol. 6, No. 1, 1994, p. 16-24.

Research output: Contribution to journalArticle

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