Organization and function of the cytoskeleton in polarized epithelial cells: a component of the protein sorting machinery

Robert W. Mays, Kenneth A Beck, W. James Nelson

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

Development and maintenance of cell-surface polarity in epithelial cells requires specialized localization of proteins to functionally and structuraally distinct plasma membrane domains. The organization of these domains is dependent upon targeted delivery of transport vesicles between different membrane compartments, and upon protein sorting in the membranes of the Golgi complex and cell surface. Increasing evidence has been gathered in recent years that cytoskeletal components facilitate these processes.

Original languageEnglish (US)
Pages (from-to)16-24
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume6
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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