Organization and chromosomal locations of Rap1a/Krev sequences in the mouse

Nancy A. Dower, Michael F Seldin, Sherri Pugh, James C. Stone

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The human RAP1A gene encodes a protein that apparently can antagonize the function of oncogenic ras genes in gene transfer experiments, but its normal function is unknown. To understand the function of this gene, we have undertaken a study of the mouse homolog, Rap1a. The complete coding sequence of a mouse Rap1a cDNA has been determined, and genomic clones representing three distinct Rap1a species were recovered. We find that Rap1a is located on distal mouse Chromosome (Chr) 3 near Nras, Ampd-1, Tshb, Ngfb, and Atp1a1. Two related sequences (Rap1a-rs1 and Rap1a-rs2) were also characterized. Rap1a-rs1, which was not localized, has a sequence very similar to the Rap1a cDNA, suggesting that it has been recently acquired by the mouse genome. Rap1a-rs2 is more distantly related to the gene sequence and is located on Chr 2 near Actc-1.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalMammalian Genome
Issue number3
StatePublished - Mar 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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