Orchestrating Cell/Material Interactions For Tissue Engineering of Surgical Implants

Achala de Mel, Alexander M. Seifalian, Martin A. Birchall

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Research groups are currently recognising a critical clinical need for innovative approaches to organ failure and agenesis. Allografting, autologous reconstruction and prosthetics are hampered with severe limitations. Pertinently, readily available 'laboratory-grown' organs and implants are becoming a reality. Tissue engineering constructs vary in their design complexity depending on the specific structural and functional demands. Expeditious methods on integrating autologous stem cells onto nanoarchitectured 3D nanocomposites, are being transferred from lab to patients with a number of successful first-in-man experiences. Despite the need for a complete understanding of cell/material interactions tissue engineering is offering a plethora of exciting possibilities in regenerative medicine. Tissue engineering scaffolds can be bio-functionalised to present receptor-specific ligands. Such surface modifications can be fine-tuned with the aid of nanotechnology for tailored cell/material interactions. Bio-functionalised nanoparticles can be used for live monitoring of cell/material interactions and biocompatibility.

Original languageEnglish (US)
Pages (from-to)1010-1021
Number of pages12
JournalMacromolecular Bioscience
Issue number8
StatePublished - Aug 2012
Externally publishedYes


  • Cells
  • Extracellular matrix
  • Nanocomposites
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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