Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle

Zoe Allen Martinez; Mark Colgan; Lewis R. Baxter; Javier Quintana; Stefan Siegel; Arion Chatziioannou; Simon R Cherry; John C. Mazziotta; Michael E. Phelps

doi:10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#

Oral ¹⁸F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle

Zoe Allen Martinez, Mark Colgan, Lewis R. Baxter, Javier Quintana, Stefan Siegel, Arion Chatziioannou, Simon R Cherry, John C. Mazziotta, Michael E. Phelps

Radiology

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

We describe a method of orally administering ¹⁸F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMR-Glcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.

Original language	English (US)
Pages (from-to)	215-224
Number of pages	10
Journal	American Journal of Primatology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#
State	Published - 1997

Keywords

Behavior
Brain metabolism
Deoxyglucose
PET scan
Primates
Restraint

ASJC Scopus subject areas

Animal Science and Zoology

Access to Document

10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#

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Martinez, Z. A., Colgan, M., Baxter, L. R., Quintana, J., Siegel, S., Chatziioannou, A., Cherry, S. R., Mazziotta, J. C., & Phelps, M. E. (1997). Oral ¹⁸F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle. American Journal of Primatology, 42(3), 215-224. https://doi.org/10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#

Oral ¹⁸F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint : Demonstration of principle. / Martinez, Zoe Allen; Colgan, Mark; Baxter, Lewis R.; Quintana, Javier; Siegel, Stefan; Chatziioannou, Arion; Cherry, Simon R; Mazziotta, John C.; Phelps, Michael E.

In: American Journal of Primatology, Vol. 42, No. 3, 1997, p. 215-224.

Research output: Contribution to journal › Article

Martinez, ZA, Colgan, M, Baxter, LR, Quintana, J, Siegel, S, Chatziioannou, A, Cherry, SR, Mazziotta, JC & Phelps, ME 1997, 'Oral ¹⁸F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle', American Journal of Primatology, vol. 42, no. 3, pp. 215-224. https://doi.org/10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#

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