Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle

Zoe Allen Martinez, Mark Colgan, Lewis R. Baxter, Javier Quintana, Stefan Siegel, Arion Chatziioannou, Simon R Cherry, John C. Mazziotta, Michael E. Phelps

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMR-Glcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.

Original languageEnglish (US)
Pages (from-to)215-224
Number of pages10
JournalAmerican Journal of Primatology
Volume42
Issue number3
DOIs
StatePublished - 1997

Keywords

  • Behavior
  • Brain metabolism
  • Deoxyglucose
  • PET scan
  • Primates
  • Restraint

ASJC Scopus subject areas

  • Animal Science and Zoology

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