Abstract
We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMR-Glcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-224 |
| Number of pages | 10 |
| Journal | American Journal of Primatology |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1997 |
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Keywords
- Behavior
- Brain metabolism
- Deoxyglucose
- PET scan
- Primates
- Restraint
ASJC Scopus subject areas
- Animal Science and Zoology
Cite this
Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint : Demonstration of principle. / Martinez, Zoe Allen; Colgan, Mark; Baxter, Lewis R.; Quintana, Javier; Siegel, Stefan; Chatziioannou, Arion; Cherry, Simon R; Mazziotta, John C.; Phelps, Michael E.
In: American Journal of Primatology, Vol. 42, No. 3, 1997, p. 215-224.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint
T2 - Demonstration of principle
AU - Martinez, Zoe Allen
AU - Colgan, Mark
AU - Baxter, Lewis R.
AU - Quintana, Javier
AU - Siegel, Stefan
AU - Chatziioannou, Arion
AU - Cherry, Simon R
AU - Mazziotta, John C.
AU - Phelps, Michael E.
PY - 1997
Y1 - 1997
N2 - We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMR-Glcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.
AB - We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMR-Glcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.
KW - Behavior
KW - Brain metabolism
KW - Deoxyglucose
KW - PET scan
KW - Primates
KW - Restraint
UR - http://www.scopus.com/inward/record.url?scp=0030612626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030612626&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#
DO - 10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#
M3 - Article
C2 - 9209586
AN - SCOPUS:0030612626
VL - 42
SP - 215
EP - 224
JO - American Journal of Primatology
JF - American Journal of Primatology
SN - 0275-2565
IS - 3
ER -