Oral mifepristone and buccal misoprostol administered simultaneously for abortion: a pilot study

Patricia A. Lohr, Matthew F. Reeves, Jennifer L. Hayes, Bryna Harwood, Mitchell D Creinin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Simultaneous oral mifepristone and vaginal misoprostol has a 24-h expulsion rate of approximately 90% when used for abortion through 63 days' gestation. This pilot study sought to determine if a simultaneous regimen using buccal misoprostol would be similarly effective and merit further investigation. Study design: One hundred twenty women were enrolled into three equal groups by gestational age: ≤49 days (Group 1), 50-56 days (Group 2) and 57-63 days (Group 3). After swallowing 200 mg of mifepristone, subjects received 800 mcg buccal misoprostol. Participants returned in 24±1 h for evaluation of expulsion by ultrasonography. Women with a persistent gestational sac received 800 mcg vaginal misoprostol. Further follow-up occurred at 1, 2 and 5 weeks by telephone or in person, as appropriate. Sample sizes for each group were estimated with the aim of establishing a 24-h expulsion rate of 90% (95% CI=76-95). Results: The 24-h expulsion rates for Groups 1, 2 and 3 were 73% (95% CI=56-85), 69% (95% CI=52-83) and 73% (95% CI=56-85), respectively. Common side effects were nausea (62%), vomiting (33%) and diarrhea (48%), which did not differ by gestational age. Forty-three percent of subjects found the taste of buccal misoprostol objectionable; 30% found buccal retention uncomfortable or inconvenient, and 10% reported oral irritation, sensitivity, numbness or oral ulcers. Conclusions: Simultaneous oral mifepristone and buccal misoprostol had a lower-than-hypothesized expulsion rate at 24 h. Although overall success rates at 7 or 15 days could have been higher than those observed at 24 h, we believe that this regimen does not warrant further study.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalContraception
Volume76
Issue number3
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Misoprostol
Mifepristone
Cheek
Gestational Age
Gestational Sac
Oral Ulcer
Hypesthesia
Deglutition
Telephone
Sample Size
Nausea
Vomiting
Diarrhea
Ultrasonography
Pregnancy

Keywords

  • Buccal administration
  • Medical abortion
  • Mifepristone
  • Misoprostol

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Oral mifepristone and buccal misoprostol administered simultaneously for abortion : a pilot study. / Lohr, Patricia A.; Reeves, Matthew F.; Hayes, Jennifer L.; Harwood, Bryna; Creinin, Mitchell D.

In: Contraception, Vol. 76, No. 3, 09.2007, p. 215-220.

Research output: Contribution to journalArticle

Lohr, Patricia A. ; Reeves, Matthew F. ; Hayes, Jennifer L. ; Harwood, Bryna ; Creinin, Mitchell D. / Oral mifepristone and buccal misoprostol administered simultaneously for abortion : a pilot study. In: Contraception. 2007 ; Vol. 76, No. 3. pp. 215-220.
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abstract = "Background: Simultaneous oral mifepristone and vaginal misoprostol has a 24-h expulsion rate of approximately 90{\%} when used for abortion through 63 days' gestation. This pilot study sought to determine if a simultaneous regimen using buccal misoprostol would be similarly effective and merit further investigation. Study design: One hundred twenty women were enrolled into three equal groups by gestational age: ≤49 days (Group 1), 50-56 days (Group 2) and 57-63 days (Group 3). After swallowing 200 mg of mifepristone, subjects received 800 mcg buccal misoprostol. Participants returned in 24±1 h for evaluation of expulsion by ultrasonography. Women with a persistent gestational sac received 800 mcg vaginal misoprostol. Further follow-up occurred at 1, 2 and 5 weeks by telephone or in person, as appropriate. Sample sizes for each group were estimated with the aim of establishing a 24-h expulsion rate of 90{\%} (95{\%} CI=76-95). Results: The 24-h expulsion rates for Groups 1, 2 and 3 were 73{\%} (95{\%} CI=56-85), 69{\%} (95{\%} CI=52-83) and 73{\%} (95{\%} CI=56-85), respectively. Common side effects were nausea (62{\%}), vomiting (33{\%}) and diarrhea (48{\%}), which did not differ by gestational age. Forty-three percent of subjects found the taste of buccal misoprostol objectionable; 30{\%} found buccal retention uncomfortable or inconvenient, and 10{\%} reported oral irritation, sensitivity, numbness or oral ulcers. Conclusions: Simultaneous oral mifepristone and buccal misoprostol had a lower-than-hypothesized expulsion rate at 24 h. Although overall success rates at 7 or 15 days could have been higher than those observed at 24 h, we believe that this regimen does not warrant further study.",
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AB - Background: Simultaneous oral mifepristone and vaginal misoprostol has a 24-h expulsion rate of approximately 90% when used for abortion through 63 days' gestation. This pilot study sought to determine if a simultaneous regimen using buccal misoprostol would be similarly effective and merit further investigation. Study design: One hundred twenty women were enrolled into three equal groups by gestational age: ≤49 days (Group 1), 50-56 days (Group 2) and 57-63 days (Group 3). After swallowing 200 mg of mifepristone, subjects received 800 mcg buccal misoprostol. Participants returned in 24±1 h for evaluation of expulsion by ultrasonography. Women with a persistent gestational sac received 800 mcg vaginal misoprostol. Further follow-up occurred at 1, 2 and 5 weeks by telephone or in person, as appropriate. Sample sizes for each group were estimated with the aim of establishing a 24-h expulsion rate of 90% (95% CI=76-95). Results: The 24-h expulsion rates for Groups 1, 2 and 3 were 73% (95% CI=56-85), 69% (95% CI=52-83) and 73% (95% CI=56-85), respectively. Common side effects were nausea (62%), vomiting (33%) and diarrhea (48%), which did not differ by gestational age. Forty-three percent of subjects found the taste of buccal misoprostol objectionable; 30% found buccal retention uncomfortable or inconvenient, and 10% reported oral irritation, sensitivity, numbness or oral ulcers. Conclusions: Simultaneous oral mifepristone and buccal misoprostol had a lower-than-hypothesized expulsion rate at 24 h. Although overall success rates at 7 or 15 days could have been higher than those observed at 24 h, we believe that this regimen does not warrant further study.

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