Oral midazolam with an antacid may increase the speed of onset of sedation in children prior to general anaesthesia

Cathleen R Lammers, J. L. Rosner, D. E. Crockett, R. Chhokra, J. G. Brock-Utne

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: The aim of the study was to see whether sodium citrate solution would speed the gastric absorption of oral midazolam. Methods: Forty presurgical ASA I and II patients (aged 2-6 years) were randomly assigned to one of two groups. Group I received midazolam 0.5 mg·kg-1 mixed with sodium citrate while group II (control) received midazolam 0.5 mg·kg-1 mixed with Hawaiian fruit punch. Results: There was no statistical difference between the ages, weights, preoperative sedation and anxiety scores in the two groups. After premedication, the onset of sedation (mean ± SD) measured by the first change in sedation score was found to be significantly faster (P < 0.05) in group I (17.8 ± 7.11) compared with group II (21.9 ± 5.34). There was no statistical difference in anxiety at any time intervals, separation or induction scoring for both groups. Gastric volumes and the pH of gastric aspirates between the two groups were not statistically significant. Conclusions: The time to onset of sedation can potentially be shortened, by using a preparation of intravenous midazolam and antacid, given orally.

Original languageEnglish (US)
Pages (from-to)26-28
Number of pages3
JournalPaediatric Anaesthesia
Volume12
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Anaesthesia
  • Antacid
  • Midazolam
  • Preoperative sedation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Oral midazolam with an antacid may increase the speed of onset of sedation in children prior to general anaesthesia'. Together they form a unique fingerprint.

  • Cite this