Oral midazolam with an antacid may increase the speed of onset of sedation in children prior to general anaesthesia

Cathleen R Lammers; J. L. Rosner; D. E. Crockett; R. Chhokra; J. G. Brock-Utne

doi:10.1046/j.1460-9592.2002.00770.x

Oral midazolam with an antacid may increase the speed of onset of sedation in children prior to general anaesthesia

Cathleen R Lammers, J. L. Rosner, D. E. Crockett, R. Chhokra, J. G. Brock-Utne

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: The aim of the study was to see whether sodium citrate solution would speed the gastric absorption of oral midazolam. Methods: Forty presurgical ASA I and II patients (aged 2-6 years) were randomly assigned to one of two groups. Group I received midazolam 0.5 mg·kg^-1 mixed with sodium citrate while group II (control) received midazolam 0.5 mg·kg^-1 mixed with Hawaiian fruit punch. Results: There was no statistical difference between the ages, weights, preoperative sedation and anxiety scores in the two groups. After premedication, the onset of sedation (mean ± SD) measured by the first change in sedation score was found to be significantly faster (P < 0.05) in group I (17.8 ± 7.11) compared with group II (21.9 ± 5.34). There was no statistical difference in anxiety at any time intervals, separation or induction scoring for both groups. Gastric volumes and the pH of gastric aspirates between the two groups were not statistically significant. Conclusions: The time to onset of sedation can potentially be shortened, by using a preparation of intravenous midazolam and antacid, given orally.

Original language	English (US)
Pages (from-to)	26-28
Number of pages	3
Journal	Paediatric Anaesthesia
Volume	12
Issue number	1
DOIs	https://doi.org/10.1046/j.1460-9592.2002.00770.x
State	Published - 2002
Externally published	Yes

Keywords

Anaesthesia
Antacid
Midazolam
Preoperative sedation

ASJC Scopus subject areas

Anesthesiology and Pain Medicine
Pediatrics, Perinatology, and Child Health

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title = "Oral midazolam with an antacid may increase the speed of onset of sedation in children prior to general anaesthesia",

abstract = "Background: The aim of the study was to see whether sodium citrate solution would speed the gastric absorption of oral midazolam. Methods: Forty presurgical ASA I and II patients (aged 2-6 years) were randomly assigned to one of two groups. Group I received midazolam 0.5 mg·kg-1 mixed with sodium citrate while group II (control) received midazolam 0.5 mg·kg-1 mixed with Hawaiian fruit punch. Results: There was no statistical difference between the ages, weights, preoperative sedation and anxiety scores in the two groups. After premedication, the onset of sedation (mean ± SD) measured by the first change in sedation score was found to be significantly faster (P < 0.05) in group I (17.8 ± 7.11) compared with group II (21.9 ± 5.34). There was no statistical difference in anxiety at any time intervals, separation or induction scoring for both groups. Gastric volumes and the pH of gastric aspirates between the two groups were not statistically significant. Conclusions: The time to onset of sedation can potentially be shortened, by using a preparation of intravenous midazolam and antacid, given orally.",

keywords = "Anaesthesia, Antacid, Midazolam, Preoperative sedation",

author = "Lammers, {Cathleen R} and Rosner, {J. L.} and Crockett, {D. E.} and R. Chhokra and Brock-Utne, {J. G.}",

year = "2002",

doi = "10.1046/j.1460-9592.2002.00770.x",

language = "English (US)",

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T1 - Oral midazolam with an antacid may increase the speed of onset of sedation in children prior to general anaesthesia

AU - Lammers, Cathleen R

AU - Rosner, J. L.

AU - Crockett, D. E.

AU - Chhokra, R.

AU - Brock-Utne, J. G.

PY - 2002

Y1 - 2002

N2 - Background: The aim of the study was to see whether sodium citrate solution would speed the gastric absorption of oral midazolam. Methods: Forty presurgical ASA I and II patients (aged 2-6 years) were randomly assigned to one of two groups. Group I received midazolam 0.5 mg·kg-1 mixed with sodium citrate while group II (control) received midazolam 0.5 mg·kg-1 mixed with Hawaiian fruit punch. Results: There was no statistical difference between the ages, weights, preoperative sedation and anxiety scores in the two groups. After premedication, the onset of sedation (mean ± SD) measured by the first change in sedation score was found to be significantly faster (P < 0.05) in group I (17.8 ± 7.11) compared with group II (21.9 ± 5.34). There was no statistical difference in anxiety at any time intervals, separation or induction scoring for both groups. Gastric volumes and the pH of gastric aspirates between the two groups were not statistically significant. Conclusions: The time to onset of sedation can potentially be shortened, by using a preparation of intravenous midazolam and antacid, given orally.

AB - Background: The aim of the study was to see whether sodium citrate solution would speed the gastric absorption of oral midazolam. Methods: Forty presurgical ASA I and II patients (aged 2-6 years) were randomly assigned to one of two groups. Group I received midazolam 0.5 mg·kg-1 mixed with sodium citrate while group II (control) received midazolam 0.5 mg·kg-1 mixed with Hawaiian fruit punch. Results: There was no statistical difference between the ages, weights, preoperative sedation and anxiety scores in the two groups. After premedication, the onset of sedation (mean ± SD) measured by the first change in sedation score was found to be significantly faster (P < 0.05) in group I (17.8 ± 7.11) compared with group II (21.9 ± 5.34). There was no statistical difference in anxiety at any time intervals, separation or induction scoring for both groups. Gastric volumes and the pH of gastric aspirates between the two groups were not statistically significant. Conclusions: The time to onset of sedation can potentially be shortened, by using a preparation of intravenous midazolam and antacid, given orally.

KW - Anaesthesia

KW - Antacid

KW - Midazolam

KW - Preoperative sedation

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