Oral irritant properties of menthol: Sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine

J. M. Dessirier, M. Mahony, Earl Carstens

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

The irritant properties of menthol and its interactions with nicotine were investigated psychophysically in human subjects. In the first experiment, 0.3% L-menthol was applied successively to one side of the tongue 10 times at a 1-min interval (30-s interstimulus interval, ISI), and subjects rated the intensity of the perceived irritation. The intensity of irritation progressively decreased across trials, consistent with desensitization. To test for cross-desensitization of nicotine-evoked irritation by menthol, nicotine (0.6%) was applied to both sides of the tongue simultaneously, 5 min after the conclusion of menthol application. Using both a two-alternative forced choice (2-AFC) paradigm, and also by obtaining independent ratings of the irritant intensity on each side of the tongue, it was found that nicotine-evoked irritation was significantly weaker on the menthol-pretreated side. To control for a possible confounding effect of cooling, nicotine was applied bilaterally only after the cooling sensation of menthol had subsided. Nicotine-induced irritation was still significantly weaker on the menthol-pretreated side, consistent with cross-desensitization of nicotine-evoked irritation by menthol. In a final experiment, menthol was repeatedly applied to one side of the tongue at a shorter (20 s) interval (5-s ISI), and elicited a rapid increase in irritant sensation over the initial trials, consistent with sensitization, followed in subsequent trials by a progressive reduction in irritation (desensitization). After a 5-min rest period, self-desensitization was confirmed. Repeated application of menthol at the same short ISI was then resumed, and resulted in a significant mean increase in irritant intensity consistent with stimulus-induced recovery (SIR).

Original languageEnglish (US)
Pages (from-to)25-36
Number of pages12
JournalPhysiology and Behavior
Volume73
Issue number1-2
DOIs
StatePublished - 2001

Keywords

  • 2-AFC
  • Desensitization
  • Menthol
  • Nicotine
  • Oral irritation
  • Psychophysics
  • Sensitization
  • Stimulus-induced recovery
  • Trigeminal

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Oral irritant properties of menthol: Sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine'. Together they form a unique fingerprint.

Cite this