Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia

Ruth Williams, Stacie Olivi, Chin-Shang Li, Michael Storm, Lola Cremer, Paul Mackert, Winfred Wang

Research output: Contribution to journalArticle

18 Scopus citations


Objectives: To determine the effects of orally administered glutamine on the resting energy expenditure (REE) and nutritional status of children and adolescents with sickle cell anemia. Methods: Twenty-seven children and adolescents (13 boys, 14 girls), 5.2 to 17.9 years old (median 11.0 years), received orally administered glutamine (600 mg/kg per day) for 24 weeks. Measures of REE and other nutritional parameters were compared at baseline and 24 weeks. Results: After 24 weeks, the patients' median REE (kcal/d) decreased by 6% (P = 0.053) as indicated by the Harris Benedict equations and by 5% (P = 0.049) as indicated by the modified equations. Patients with less than 90% ideal body weight had even greater declines in REE after 24 weeks (P < 0.03 and 0.02, respectively). Improvements in nutrition parameters and in two amino acids in the plasma were observed. Conclusions: After 24 weeks of orally administered glutamine, children and adolescents with sickle cell anemia had a decrease in REE and improvement in nutritional parameters. Those who were underweight had a greater decrease in REE than those of normal body weight. Lowering REE may be an effective way to improve the growth of these children and adolescents.

Original languageEnglish (US)
Pages (from-to)619-625
Number of pages7
JournalJournal of Pediatric Hematology/Oncology
Issue number10
StatePublished - Oct 2004
Externally publishedYes



  • Amino acids
  • Glutamine
  • Nutrition
  • Sickle cell anemia
  • Sickle cell disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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