Abstract
Objectives: To determine the effects of orally administered glutamine on the resting energy expenditure (REE) and nutritional status of children and adolescents with sickle cell anemia. Methods: Twenty-seven children and adolescents (13 boys, 14 girls), 5.2 to 17.9 years old (median 11.0 years), received orally administered glutamine (600 mg/kg per day) for 24 weeks. Measures of REE and other nutritional parameters were compared at baseline and 24 weeks. Results: After 24 weeks, the patients' median REE (kcal/d) decreased by 6% (P = 0.053) as indicated by the Harris Benedict equations and by 5% (P = 0.049) as indicated by the modified equations. Patients with less than 90% ideal body weight had even greater declines in REE after 24 weeks (P < 0.03 and 0.02, respectively). Improvements in nutrition parameters and in two amino acids in the plasma were observed. Conclusions: After 24 weeks of orally administered glutamine, children and adolescents with sickle cell anemia had a decrease in REE and improvement in nutritional parameters. Those who were underweight had a greater decrease in REE than those of normal body weight. Lowering REE may be an effective way to improve the growth of these children and adolescents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 619-625 |
| Number of pages | 7 |
| Journal | Journal of Pediatric Hematology/Oncology |
| Volume | 26 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2004 |
| Externally published | Yes |
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Keywords
- Amino acids
- Glutamine
- Nutrition
- Sickle cell anemia
- Sickle cell disease
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Hematology
Cite this
Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia. / Williams, Ruth; Olivi, Stacie; Li, Chin-Shang; Storm, Michael; Cremer, Lola; Mackert, Paul; Wang, Winfred.
In: Journal of Pediatric Hematology/Oncology, Vol. 26, No. 10, 10.2004, p. 619-625.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia
AU - Williams, Ruth
AU - Olivi, Stacie
AU - Li, Chin-Shang
AU - Storm, Michael
AU - Cremer, Lola
AU - Mackert, Paul
AU - Wang, Winfred
PY - 2004/10
Y1 - 2004/10
N2 - Objectives: To determine the effects of orally administered glutamine on the resting energy expenditure (REE) and nutritional status of children and adolescents with sickle cell anemia. Methods: Twenty-seven children and adolescents (13 boys, 14 girls), 5.2 to 17.9 years old (median 11.0 years), received orally administered glutamine (600 mg/kg per day) for 24 weeks. Measures of REE and other nutritional parameters were compared at baseline and 24 weeks. Results: After 24 weeks, the patients' median REE (kcal/d) decreased by 6% (P = 0.053) as indicated by the Harris Benedict equations and by 5% (P = 0.049) as indicated by the modified equations. Patients with less than 90% ideal body weight had even greater declines in REE after 24 weeks (P < 0.03 and 0.02, respectively). Improvements in nutrition parameters and in two amino acids in the plasma were observed. Conclusions: After 24 weeks of orally administered glutamine, children and adolescents with sickle cell anemia had a decrease in REE and improvement in nutritional parameters. Those who were underweight had a greater decrease in REE than those of normal body weight. Lowering REE may be an effective way to improve the growth of these children and adolescents.
AB - Objectives: To determine the effects of orally administered glutamine on the resting energy expenditure (REE) and nutritional status of children and adolescents with sickle cell anemia. Methods: Twenty-seven children and adolescents (13 boys, 14 girls), 5.2 to 17.9 years old (median 11.0 years), received orally administered glutamine (600 mg/kg per day) for 24 weeks. Measures of REE and other nutritional parameters were compared at baseline and 24 weeks. Results: After 24 weeks, the patients' median REE (kcal/d) decreased by 6% (P = 0.053) as indicated by the Harris Benedict equations and by 5% (P = 0.049) as indicated by the modified equations. Patients with less than 90% ideal body weight had even greater declines in REE after 24 weeks (P < 0.03 and 0.02, respectively). Improvements in nutrition parameters and in two amino acids in the plasma were observed. Conclusions: After 24 weeks of orally administered glutamine, children and adolescents with sickle cell anemia had a decrease in REE and improvement in nutritional parameters. Those who were underweight had a greater decrease in REE than those of normal body weight. Lowering REE may be an effective way to improve the growth of these children and adolescents.
KW - Amino acids
KW - Glutamine
KW - Nutrition
KW - Sickle cell anemia
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=5344259072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5344259072&partnerID=8YFLogxK
U2 - 10.1097/01.mph.0000140651.65591.b8
DO - 10.1097/01.mph.0000140651.65591.b8
M3 - Article
C2 - 15454831
AN - SCOPUS:5344259072
VL - 26
SP - 619
EP - 625
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 10
ER -