Abstract
While essential hypertension may be characterized by insulin resistance, it is unclear which defect is primary. We therefore compared normotensive Sprague-Dawley male rats who drank N-nitro-l-arginine methyl ester (L-NAME, 1 mg/mL in distilled water), with control rats who drank distilled water. Blood pressure was measured noninvasively, weight was controlled by dietary restriction, and glucose tolerance was assessed via oral glucose tolerance tests (OGTT). Blood pressure rose by the second day of L-NAME treatment, and remained elevated throughout the study, in contrast to the rats drinking water (P < .001). Weight rose similarly in both groups. OGTT were performed after 2 weeks of L-NAME. Serum glucose and insulin responses, assessed by two-way ANOVA, were similar in the two groups (P = NS). In summary, L-NAME administration resulted in hypertension, but not a deterioration in glucose tolerance in diet-controlled Sprague-Dawley rats. We conclude that the insulin resistance of some hypertensive states is not the result of hypertension per se, or increased vasoconstriction, such as might result from inhibition of endogenous nitric oxide synthesis, but rather indicates a fundamental metabolic disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1009-1014 |
| Number of pages | 6 |
| Journal | American Journal of Hypertension |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| State | Published - 1995 |
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Keywords
- hypertension
- insulin resistance
- N-nitro-l-arginine methyl ester (L-NAME)
- Nitric oxide
- Sprague-Dawley rat
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Oral administration of the nitric oxide biosynthesis inhibitor, N-nitro-l-arginine methyl ester (L-NAME), causes hypertension, but not glucose intolerance or insulin resistance, in rats. / Swislocki, Arthur L; Eason, Teresa; Kaysen, George.
In: American Journal of Hypertension, Vol. 8, No. 10, 1995, p. 1009-1014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral administration of the nitric oxide biosynthesis inhibitor, N-nitro-l-arginine methyl ester (L-NAME), causes hypertension, but not glucose intolerance or insulin resistance, in rats
AU - Swislocki, Arthur L
AU - Eason, Teresa
AU - Kaysen, George
PY - 1995
Y1 - 1995
N2 - While essential hypertension may be characterized by insulin resistance, it is unclear which defect is primary. We therefore compared normotensive Sprague-Dawley male rats who drank N-nitro-l-arginine methyl ester (L-NAME, 1 mg/mL in distilled water), with control rats who drank distilled water. Blood pressure was measured noninvasively, weight was controlled by dietary restriction, and glucose tolerance was assessed via oral glucose tolerance tests (OGTT). Blood pressure rose by the second day of L-NAME treatment, and remained elevated throughout the study, in contrast to the rats drinking water (P < .001). Weight rose similarly in both groups. OGTT were performed after 2 weeks of L-NAME. Serum glucose and insulin responses, assessed by two-way ANOVA, were similar in the two groups (P = NS). In summary, L-NAME administration resulted in hypertension, but not a deterioration in glucose tolerance in diet-controlled Sprague-Dawley rats. We conclude that the insulin resistance of some hypertensive states is not the result of hypertension per se, or increased vasoconstriction, such as might result from inhibition of endogenous nitric oxide synthesis, but rather indicates a fundamental metabolic disorder.
AB - While essential hypertension may be characterized by insulin resistance, it is unclear which defect is primary. We therefore compared normotensive Sprague-Dawley male rats who drank N-nitro-l-arginine methyl ester (L-NAME, 1 mg/mL in distilled water), with control rats who drank distilled water. Blood pressure was measured noninvasively, weight was controlled by dietary restriction, and glucose tolerance was assessed via oral glucose tolerance tests (OGTT). Blood pressure rose by the second day of L-NAME treatment, and remained elevated throughout the study, in contrast to the rats drinking water (P < .001). Weight rose similarly in both groups. OGTT were performed after 2 weeks of L-NAME. Serum glucose and insulin responses, assessed by two-way ANOVA, were similar in the two groups (P = NS). In summary, L-NAME administration resulted in hypertension, but not a deterioration in glucose tolerance in diet-controlled Sprague-Dawley rats. We conclude that the insulin resistance of some hypertensive states is not the result of hypertension per se, or increased vasoconstriction, such as might result from inhibition of endogenous nitric oxide synthesis, but rather indicates a fundamental metabolic disorder.
KW - hypertension
KW - insulin resistance
KW - N-nitro-l-arginine methyl ester (L-NAME)
KW - Nitric oxide
KW - Sprague-Dawley rat
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UR - http://www.scopus.com/inward/citedby.url?scp=0028851674&partnerID=8YFLogxK
U2 - 10.1016/0895-7061(95)00161-1
DO - 10.1016/0895-7061(95)00161-1
M3 - Article
C2 - 8845069
AN - SCOPUS:0028851674
VL - 8
SP - 1009
EP - 1014
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 10
ER -