Optimizing the Diagnosis and Biomarker Testing for Patients with Intrahepatic Cholangiocarcinoma: A Multidisciplinary Approach

May T. Cho, Sepideh Gholami, Dorina Gui, Sooraj L. Tejaswi, Ghaneh Fananapazir, Nadine Abi-Jaoudeh, Zeljka Jutric, Jason B. Samarasena, Xiaodong Li, Jennifer B. Valerin, Jacob Mercer, Farshid Dayyani

Research output: Contribution to journalReview articlepeer-review

Abstract

Cholangiocarcinoma (CCA) is a heterogenous group of malignancies originating in the biliary tree, and associated with poor prognosis. Until recently, treatment options have been limited to surgical resection, liver-directed therapies, and chemotherapy. Identification of actionable genomic alterations with biomarker testing has revolutionized the treatment paradigm for these patients. However, several challenges exist to the seamless adoption of precision medicine in patients with CCA, relating to a lack of awareness of the importance of biomarker testing, hurdles in tissue acquisition, and ineffective collaboration among the multidisciplinary team (MDT). To identify gaps in standard practices and define best practices, multidisciplinary hepatobiliary teams from the University of California (UC) Davis and UC Irvine were convened; discussions of the meeting, including optimal approaches to tissue acquisition for diagnosis and biomarker testing, communication among academic and community healthcare teams, and physician education regarding biomarker testing, are summarized in this review.

Original languageEnglish (US)
Article number392
JournalCancers
Volume14
Issue number2
DOIs
StatePublished - Jan 1 2022
Externally publishedYes

Keywords

  • Best practices
  • Biomarker testing
  • Challenges
  • Cholangiocarcinoma
  • Genomic alterations
  • Multidisciplinary
  • Next-generation sequencing
  • Precision medicine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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