Optimizing the Design and Analysis of Clinical Functional Magnetic Resonance Imaging Research Studies

Cameron S Carter, Stephan Heckers, Thomas Nichols, Daniel S. Pine, Stephen Strother

Research output: Contribution to journalArticle

52 Scopus citations


With the widespread availability of functional magnetic resonance imaging (fMRI), there has been rapid progress in identifying neural correlates of cognition and emotion in the human brain. In conjunction with basic research studies, fMRI has been increasingly applied in clinical disorders, making it a central research tool in human psychopathology, psychopharmacology, and genetics. In the present article, we discuss a number of conceptual and methodological challenges that confront the implementation of fMRI in clinical and translational research, and we offer a set of recommendations intended to enhance the interpretability and reproducibility of results in clinical fMRI.

Original languageEnglish (US)
Pages (from-to)842-849
Number of pages8
JournalBiological Psychiatry
Issue number10
StatePublished - Nov 15 2008



  • Analysis
  • best practices
  • clinical and translational neuroscience
  • data presentation
  • experimental design
  • fMRI

ASJC Scopus subject areas

  • Biological Psychiatry

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