Abstract
Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 836-846 |
| Number of pages | 11 |
| Journal | Epilepsia |
| Volume | 43 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
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Keywords
- Afterdischarges
- Cortical stimulation
- Electrical stimulation
- Epilepsy
- Seizure
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Optimizing parameters for terminating cortical afterdischarges with pulse stimulation. / Motamedi, Gholam K.; Lesser, Ronald P.; Miglioretti, Diana L; Mizuno-Matsumoto, Yuko; Gordon, Barry; Webber, William R S; Jackson, Darryl C.; Sepkuty, Jehuda P.; Crone, Nathan E.
In: Epilepsia, Vol. 43, No. 8, 2002, p. 836-846.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimizing parameters for terminating cortical afterdischarges with pulse stimulation
AU - Motamedi, Gholam K.
AU - Lesser, Ronald P.
AU - Miglioretti, Diana L
AU - Mizuno-Matsumoto, Yuko
AU - Gordon, Barry
AU - Webber, William R S
AU - Jackson, Darryl C.
AU - Sepkuty, Jehuda P.
AU - Crone, Nathan E.
PY - 2002
Y1 - 2002
N2 - Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.
AB - Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.
KW - Afterdischarges
KW - Cortical stimulation
KW - Electrical stimulation
KW - Epilepsy
KW - Seizure
UR - http://www.scopus.com/inward/record.url?scp=0036337952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036337952&partnerID=8YFLogxK
U2 - 10.1046/j.1528-1157.2002.24901.x
DO - 10.1046/j.1528-1157.2002.24901.x
M3 - Article
VL - 43
SP - 836
EP - 846
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 8
ER -