Optimizing parameters for terminating cortical afterdischarges with pulse stimulation

Gholam K. Motamedi, Ronald P. Lesser, Diana L Miglioretti, Yuko Mizuno-Matsumoto, Barry Gordon, William R S Webber, Darryl C. Jackson, Jehuda P. Sepkuty, Nathan E. Crone

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.

Original languageEnglish (US)
Pages (from-to)836-846
Number of pages11
JournalEpilepsia
Volume43
Issue number8
DOIs
StatePublished - 2002
Externally publishedYes

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Electric Stimulation
Electrodes
Implanted Electrodes

Keywords

  • Afterdischarges
  • Cortical stimulation
  • Electrical stimulation
  • Epilepsy
  • Seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Motamedi, G. K., Lesser, R. P., Miglioretti, D. L., Mizuno-Matsumoto, Y., Gordon, B., Webber, W. R. S., ... Crone, N. E. (2002). Optimizing parameters for terminating cortical afterdischarges with pulse stimulation. Epilepsia, 43(8), 836-846. https://doi.org/10.1046/j.1528-1157.2002.24901.x

Optimizing parameters for terminating cortical afterdischarges with pulse stimulation. / Motamedi, Gholam K.; Lesser, Ronald P.; Miglioretti, Diana L; Mizuno-Matsumoto, Yuko; Gordon, Barry; Webber, William R S; Jackson, Darryl C.; Sepkuty, Jehuda P.; Crone, Nathan E.

In: Epilepsia, Vol. 43, No. 8, 2002, p. 836-846.

Research output: Contribution to journalArticle

Motamedi, GK, Lesser, RP, Miglioretti, DL, Mizuno-Matsumoto, Y, Gordon, B, Webber, WRS, Jackson, DC, Sepkuty, JP & Crone, NE 2002, 'Optimizing parameters for terminating cortical afterdischarges with pulse stimulation', Epilepsia, vol. 43, no. 8, pp. 836-846. https://doi.org/10.1046/j.1528-1157.2002.24901.x
Motamedi, Gholam K. ; Lesser, Ronald P. ; Miglioretti, Diana L ; Mizuno-Matsumoto, Yuko ; Gordon, Barry ; Webber, William R S ; Jackson, Darryl C. ; Sepkuty, Jehuda P. ; Crone, Nathan E. / Optimizing parameters for terminating cortical afterdischarges with pulse stimulation. In: Epilepsia. 2002 ; Vol. 43, No. 8. pp. 836-846.
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