Optimizing parameters for terminating cortical afterdischarges with pulse stimulation

Gholam K. Motamedi; Ronald P. Lesser; Diana L Miglioretti; Yuko Mizuno-Matsumoto; Barry Gordon; William R S Webber; Darryl C. Jackson; Jehuda P. Sepkuty; Nathan E. Crone

doi:10.1046/j.1528-1157.2002.24901.x

Optimizing parameters for terminating cortical afterdischarges with pulse stimulation

Gholam K. Motamedi, Ronald P. Lesser, Diana L Miglioretti, Yuko Mizuno-Matsumoto, Barry Gordon, William R S Webber, Darryl C. Jackson, Jehuda P. Sepkuty, Nathan E. Crone

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.

Original language	English (US)
Pages (from-to)	836-846
Number of pages	11
Journal	Epilepsia
Volume	43
Issue number	8
DOIs	https://doi.org/10.1046/j.1528-1157.2002.24901.x
State	Published - 2002
Externally published	Yes

Keywords

Afterdischarges
Cortical stimulation
Electrical stimulation
Epilepsy
Seizure

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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Optimizing parameters for terminating cortical afterdischarges with pulse stimulation. / Motamedi, Gholam K.; Lesser, Ronald P.; Miglioretti, Diana L; Mizuno-Matsumoto, Yuko; Gordon, Barry; Webber, William R S; Jackson, Darryl C.; Sepkuty, Jehuda P.; Crone, Nathan E.

In: Epilepsia, Vol. 43, No. 8, 2002, p. 836-846.

Research output: Contribution to journal › Article › peer-review

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abstract = "Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.",

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AU - Motamedi, Gholam K.

AU - Lesser, Ronald P.

AU - Miglioretti, Diana L

AU - Mizuno-Matsumoto, Yuko

AU - Gordon, Barry

AU - Webber, William R S

AU - Jackson, Darryl C.

AU - Sepkuty, Jehuda P.

AU - Crone, Nathan E.

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N2 - Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.

AB - Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.

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Optimizing parameters for terminating cortical afterdischarges with pulse stimulation

Abstract

Keywords

ASJC Scopus subject areas

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