Optimization of real-time high frequency ultrasound for blood flow imaging in the microcirculation

D. E. Kruse, J. J. Mai, R. H. Silverman, M. F. Insana, D. J. Coleman, K. W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The first high frequency ultrasound system able to image blood flow in the microcirculation in real-time has been developed. 2-D color flow frames are rapidly acquired using a recently reported method to achieve frame rates approaching 10 fps. A new flow phantom was constructed in order to tune the wall filter order, cutoff and attenuation for a 25 MHz, f/2 transducer. RF data were acquired in both M-mode and swept-mode, and processed in order to tune the wall filter. These filters were then used in making controlled measurements of flow velocity and volume flow rate for a typical PRF of 500 Hz (1 mm/sec scan speed). Over the input of mean axial velocities ranging from 0.3 to 3.0 mm/sec (0.88 to 8.8 mm/sec angle corrected), the measured mean and maximum flow velocities were linear, with slight over-estimation of mean velocities due to the wall filter cutoff. Without correction for finite beam size, the volume flow rates were over-estimated by a factor of 2. The color flow settings were then applied to image microcirculatory flow within the nail bed of a human finger, where they were tested and optimized for a variety of vessel sizes and flow velocities.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsM.F. Insana, K.K. Shung
Pages284-292
Number of pages9
Volume4325
DOIs
StatePublished - 2001
EventMedical Imaging 2001: Ultrasonic Imaging and Signal Processing - San Diego, CA, United States
Duration: Feb 21 2001Feb 22 2001

Other

OtherMedical Imaging 2001: Ultrasonic Imaging and Signal Processing
CountryUnited States
CitySan Diego, CA
Period2/21/012/22/01

Fingerprint

Microcirculation
blood flow
Flow velocity
Blood
flow velocity
Ultrasonics
Imaging techniques
optimization
filters
Flow rate
Color
Nails
cut-off
Transducers
color
vessels
beds
transducers
attenuation

Keywords

  • Color flow
  • Microcirculation
  • Ultrasound imaging
  • Velocity estimation
  • Wall filter

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kruse, D. E., Mai, J. J., Silverman, R. H., Insana, M. F., Coleman, D. J., & Ferrara, K. W. (2001). Optimization of real-time high frequency ultrasound for blood flow imaging in the microcirculation. In M. F. Insana, & K. K. Shung (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4325, pp. 284-292) https://doi.org/10.1117/12.428203

Optimization of real-time high frequency ultrasound for blood flow imaging in the microcirculation. / Kruse, D. E.; Mai, J. J.; Silverman, R. H.; Insana, M. F.; Coleman, D. J.; Ferrara, K. W.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / M.F. Insana; K.K. Shung. Vol. 4325 2001. p. 284-292.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kruse, DE, Mai, JJ, Silverman, RH, Insana, MF, Coleman, DJ & Ferrara, KW 2001, Optimization of real-time high frequency ultrasound for blood flow imaging in the microcirculation. in MF Insana & KK Shung (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4325, pp. 284-292, Medical Imaging 2001: Ultrasonic Imaging and Signal Processing, San Diego, CA, United States, 2/21/01. https://doi.org/10.1117/12.428203
Kruse DE, Mai JJ, Silverman RH, Insana MF, Coleman DJ, Ferrara KW. Optimization of real-time high frequency ultrasound for blood flow imaging in the microcirculation. In Insana MF, Shung KK, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4325. 2001. p. 284-292 https://doi.org/10.1117/12.428203
Kruse, D. E. ; Mai, J. J. ; Silverman, R. H. ; Insana, M. F. ; Coleman, D. J. ; Ferrara, K. W. / Optimization of real-time high frequency ultrasound for blood flow imaging in the microcirculation. Proceedings of SPIE - The International Society for Optical Engineering. editor / M.F. Insana ; K.K. Shung. Vol. 4325 2001. pp. 284-292
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