Optimization of real-time high frequency ultrasound for blood flow imaging in the microcirculation

D. E. Kruse, J. J. Mai, R. H. Silverman, M. F. Insana, D. J. Coleman, K. W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


The first high frequency ultrasound system able to image blood flow in the microcirculation in real-time has been developed. 2-D color flow frames are rapidly acquired using a recently reported method to achieve frame rates approaching 10 fps. A new flow phantom was constructed in order to tune the wall filter order, cutoff and attenuation for a 25 MHz, f/2 transducer. RF data were acquired in both M-mode and swept-mode, and processed in order to tune the wall filter. These filters were then used in making controlled measurements of flow velocity and volume flow rate for a typical PRF of 500 Hz (1 mm/sec scan speed). Over the input of mean axial velocities ranging from 0.3 to 3.0 mm/sec (0.88 to 8.8 mm/sec angle corrected), the measured mean and maximum flow velocities were linear, with slight over-estimation of mean velocities due to the wall filter cutoff. Without correction for finite beam size, the volume flow rates were over-estimated by a factor of 2. The color flow settings were then applied to image microcirculatory flow within the nail bed of a human finger, where they were tested and optimized for a variety of vessel sizes and flow velocities.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsM.F. Insana, K.K. Shung
Number of pages9
StatePublished - 2001
EventMedical Imaging 2001: Ultrasonic Imaging and Signal Processing - San Diego, CA, United States
Duration: Feb 21 2001Feb 22 2001


OtherMedical Imaging 2001: Ultrasonic Imaging and Signal Processing
Country/TerritoryUnited States
CitySan Diego, CA


  • Color flow
  • Microcirculation
  • Ultrasound imaging
  • Velocity estimation
  • Wall filter

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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