Optimization of PET system design for lesion detection

Jinyi Qi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Traditionally, the figures of merit used in designing a positron emission tomography (PET) scanner are spatial resolution, noise equivalent count rate, noise equivalent sensitivity, etc. These measures, however, do not directly reflect the lesion detectability using the PET scanner. Here we propose to optimize PET scanner design directly for lesion detection. The signal-to-noise ratio (SNR) of lesion detection can be easily computed using the theoretical expressions that we have previously derived. Because no time-consuming Monte Carlo simulation is needed, the theoretical expressions allow evaluation of a large range of parameters. The PET system parameters can then be chosen to achieve the maximum SNR for lesion detection. The simulation study shown in this paper was focused on a single ring PET scanner without depth of interaction measurement. It can be extended to multiring (two- or three-dimensional) PET scanners and detectors with depth of interaction measurement.

Original languageEnglish (US)
Pages (from-to)1470-1476
Number of pages7
JournalIEEE Transactions on Nuclear Science
Volume48
Issue number4 II
DOIs
StatePublished - Aug 2001
Externally publishedYes

Fingerprint

Positron emission tomography
systems engineering
lesions
positrons
tomography
scanners
Systems analysis
optimization
Signal to noise ratio
signal to noise ratios
figure of merit
simulation
spatial resolution
interactions
Detectors
evaluation
sensitivity
rings
detectors

Keywords

  • Lesion detection
  • Optimization methods
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Optimization of PET system design for lesion detection. / Qi, Jinyi.

In: IEEE Transactions on Nuclear Science, Vol. 48, No. 4 II, 08.2001, p. 1470-1476.

Research output: Contribution to journalArticle

Qi, Jinyi. / Optimization of PET system design for lesion detection. In: IEEE Transactions on Nuclear Science. 2001 ; Vol. 48, No. 4 II. pp. 1470-1476.
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