Optimization of PET system design for lesion detection

Jinyi Qi

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Traditionally, the figures of merit used in designing a positron emission tomography (PET) scanner are spatial resolution, noise equivalent count rate, noise equivalent sensitivity, etc. These measures, however, do not directly reflect the lesion detectability using the PET scanner. Here we propose to optimize PET scanner design directly for lesion detection. The signal-to-noise ratio (SNR) of lesion detection can be easily computed using the theoretical expressions that we have previously derived. Because no time-consuming Monte Carlo simulation is needed, the theoretical expressions allow evaluation of a large range of parameters. The PET system parameters can then be chosen to achieve the maximum SNR for lesion detection. The simulation study shown in this paper was focused on a single ring PET scanner without depth of interaction measurement. It can be extended to multiring (two- or three-dimensional) PET scanners and detectors with depth of interaction measurement.

Original languageEnglish (US)
Pages (from-to)1470-1476
Number of pages7
JournalIEEE Transactions on Nuclear Science
Issue number4 II
StatePublished - Aug 2001
Externally publishedYes


  • Lesion detection
  • Optimization methods
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering


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