Optimization of PET instrumentation for brain activation studies

Magnus Dahlbom, Simon R. Cherry, Lars Eriksson, Edward J. Hoffman, Klaus Wienhard

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


By performing cerebral blood flow studies with position emission tomography (PET), and comparing blood flow images of different states of activation, functional mapping of the brain is possible. The ability of current commercial instruments to perform such studies is investigated in this work, based on a comparison of noise equivalent count (NEC) rates. Differences in the NEC performance of the different scanners in conjunctions with scanner design parameters, provide insights into the importance of block design (size, dead time, crystal thickness) and overall scanner design (sensitivity and scatter fraction) for optimizing data from activations studies. The newer scanners with removable septa, operating with 3-D acquisition, have much higher sensitivity, but administering multiple low doses (fractionation) of the flow tracer can the high sensitivity be utilized.

Original languageEnglish (US)
Pages (from-to)1048-1054
Number of pages7
JournalIEEE Transactions on Nuclear Science
Issue number4 pt 1
StatePublished - Aug 1993
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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