Optimization of PET instrumentation for brain activation studies

Magnus Dahlbom, Simon R Cherry, Lars Eriksson, Edward J. Hoffman, Klaus Wienhard

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

By performing cerebral blood flow studies with position emission tomography (PET), and comparing blood flow images of different states of activation, functional mapping of the brain is possible. The ability of current commercial instruments to perform such studies is investigated in this work, based on a comparison of noise equivalent count (NEC) rates. Differences in the NEC performance of the different scanners in conjunctions with scanner design parameters, provide insights into the importance of block design (size, dead time, crystal thickness) and overall scanner design (sensitivity and scatter fraction) for optimizing data from activations studies. The newer scanners with removable septa, operating with 3-D acquisition, have much higher sensitivity, but administering multiple low doses (fractionation) of the flow tracer can the high sensitivity be utilized.

Original languageEnglish (US)
Pages (from-to)1048-1054
Number of pages7
JournalIEEE Transactions on Nuclear Science
Volume40
Issue number4 pt 1
DOIs
StatePublished - Aug 1993

Fingerprint

scanners
brain
Tomography
Brain
tomography
Chemical activation
activation
optimization
Blood
blood flow
sensitivity
Fractionation
septum
fractionation
tracers
acquisition
Crystals
dosage
crystals

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

Cite this

Optimization of PET instrumentation for brain activation studies. / Dahlbom, Magnus; Cherry, Simon R; Eriksson, Lars; Hoffman, Edward J.; Wienhard, Klaus.

In: IEEE Transactions on Nuclear Science, Vol. 40, No. 4 pt 1, 08.1993, p. 1048-1054.

Research output: Contribution to journalArticle

Dahlbom, M, Cherry, SR, Eriksson, L, Hoffman, EJ & Wienhard, K 1993, 'Optimization of PET instrumentation for brain activation studies', IEEE Transactions on Nuclear Science, vol. 40, no. 4 pt 1, pp. 1048-1054. https://doi.org/10.1109/23.256711
Dahlbom, Magnus ; Cherry, Simon R ; Eriksson, Lars ; Hoffman, Edward J. ; Wienhard, Klaus. / Optimization of PET instrumentation for brain activation studies. In: IEEE Transactions on Nuclear Science. 1993 ; Vol. 40, No. 4 pt 1. pp. 1048-1054.
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