Optimization of microbubble destruction

James Chomas, Paul Dayton, Karen Morgan, John Allen, Kathy Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations


The rapid destruction of an ultrasound contrast agent on the time scale of microseconds which occurs when the bubble fragments provides the opportunity to distinguish echoes from bubbles and tissue. Fragmentation occurs when non-spherical oscillations in the bubble become large enough to produce a pinch-off of bubble fragments. We find that two factors are important in gauging the probability of fragmentation, the ratio of maximum expansion diameter to minimum compression diameter and the peak wall velocity. For wideband insonation (1-2 cycle insonation), the maximum expansion of a bubble relative to the initial diameter and the occurrence of fragmentation increase with decreasing bubble initial diameter. The ratio of expansion and the occurrence of fragmentation also increase with decreasing center frequency of insonation. For all frequencies and initial diameters, an increase in transmitted peak negative pressure yields increased expansion ratio and occurrence of fragmentation. A dependence of fragmentation on the phase of insonation is observed. A transmitted pulse of 0° phase (compression precedes rarefaction) produces fragmentation less than the same pulse but of phase 180° (rarefaction precedes compression). The maximum expansion of the bubble is larger in the 0° case but the wall velocity is larger in the 180° case.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
Number of pages4
StatePublished - 1999
Event1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA
Duration: Oct 17 1999Oct 20 1999


Other1999 IEEE Ultrasonics Symposium
CityCaesars Tahoe, NV, USA

ASJC Scopus subject areas

  • Engineering(all)


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