Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Feng Chen Bi, Xin He Yang, Xiao Yu Cheng, Wen Bin Deng, Xiao Li Guo, Hui Yang, Yin Wang, Juan Li, Yao Yao

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to meet research needs for AD. However, recent three-dimensional (3D) cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of AD. In this review, we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models, and propose possible solutions, in order to improve their application in AD research. Ethical concerns associated with human cerebral organoids are also discussed. We also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.

Original languageEnglish (US)
Article number27
JournalTranslational Neurodegeneration
Issue number1
StatePublished - Dec 2021
Externally publishedYes


  • Alzheimer’s disease
  • Cerebral organoids
  • Pluripotent stem cells

ASJC Scopus subject areas

  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


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