Optimal whole-body PET scanner configurations for different volumes of LSO scintillator: A simulation study

Jonathan K. Poon, Magnus L. Dahlbom, William W. Moses, Karthik Balakrishnan, Wenli Wang, Simon R Cherry, Ramsey D Badawi

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The axial field of view (AFOV) of the current generation of clinical whole-body PET scanners range from 1522cm, which limits sensitivity and renders applications such as whole-body dynamic imaging or imaging of very low activities in whole-body cellular tracking studies, almost impossible. Generally, extending the AFOV significantly increases the sensitivity and count-rate performance. However, extending the AFOV while maintaining detector thickness has significant cost implications. In addition, random coincidences, detector dead time, and object attenuation may reduce scanner performance as the AFOV increases. In this paper, we use Monte Carlo simulations to find the optimal scanner geometry (i.e. AFOV, detector thickness and acceptance angle) based on count-rate performance for a range of scintillator volumes ranging from 10 to 93 l with detector thickness varying from 5 to 20mm. We compare the results to the performance of a scanner based on the current Siemens Biograph mCT geometry and electronics. Our simulation models were developed based on individual components of the Siemens Biograph mCT and were validated against experimental data using the NEMA NU-2 2007 count-rate protocol. In the study, noise-equivalent count rate (NECR) was computed as a function of maximum ring difference (i.e. acceptance angle) and activity concentration using a 27cm diameter, 200cm uniformly filled cylindrical phantom for each scanner configuration. To reduce the effect of random coincidences, we implemented a variable coincidence time window based on the length of the lines of response, which increased NECR performance up to 10% compared to using a static coincidence time window for scanners with a large maximum ring difference values. For a given scintillator volume, the optimal configuration results in modest count-rate performance gains of up to 16% compared to the shortest AFOV scanner with the thickest detectors. However, the longest AFOV of approximately 2m with 20mm thick detectors resulted in performance gains of 2531times higher NECR relative to the current Siemens Biograph mCT scanner configuration.

Original languageEnglish (US)
Pages (from-to)4077-4094
Number of pages18
JournalPhysics in Medicine and Biology
Volume57
Issue number13
DOIs
StatePublished - Jul 7 2012

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Optimal whole-body PET scanner configurations for different volumes of LSO scintillator : A simulation study. / Poon, Jonathan K.; Dahlbom, Magnus L.; Moses, William W.; Balakrishnan, Karthik; Wang, Wenli; Cherry, Simon R; Badawi, Ramsey D.

In: Physics in Medicine and Biology, Vol. 57, No. 13, 07.07.2012, p. 4077-4094.

Research output: Contribution to journalArticle

Poon, Jonathan K. ; Dahlbom, Magnus L. ; Moses, William W. ; Balakrishnan, Karthik ; Wang, Wenli ; Cherry, Simon R ; Badawi, Ramsey D. / Optimal whole-body PET scanner configurations for different volumes of LSO scintillator : A simulation study. In: Physics in Medicine and Biology. 2012 ; Vol. 57, No. 13. pp. 4077-4094.
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