Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction: A consensus review and recommendations from the enhanced recovery after surgery society

Joseph C. Dort, D Gregory Farwell, Merran Findlay, Gerhard F. Huber, Paul Kerr, Melissa A. Shea-Budgell, Christian Simon, Jeffrey Uppington, David Zygun, Olle Ljungqvist, Jeffrey Harris

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

IMPORTANCE: Head and neck cancers often require complex, labor-intensive surgeries, especially when free flap reconstruction is required. Enhanced recovery is important in this patient population but evidence-based protocols on perioperative care for this population are lacking. OBJECTIVE: To provide a consensus-based protocol for optimal perioperative care of patients undergoing head and neck cancer surgery with free flap reconstruction. EVIDENCE REVIEW: Following endorsement by the Enhanced Recovery After Surgery (ERAS) Society to develop this protocol, a systematic review was conducted for each topic. The PubMed and Cochrane databases were initially searched to identify relevant publications on head and neck cancer surgery from 1965 through April 2015. Consistent key words for each topic included "head and neck surgery," "pharyngectomy," "laryngectomy," "laryngopharyngectomy," "neck dissection,""parotid lymphadenectomy,""thyroidectomy,""oral cavity resection,""glossectomy," and "head and neck." The final selection of literature included meta-analyses and systematic reviews as well as randomized controlled trials where available. In the absence of high-level data, case series and nonrandomized studies in head and neck cancer surgery patients or randomized controlled trials and systematic reviews in non-head and neck cancer surgery patients, were considered. An international panel of experts in major head and neck cancer surgery and enhanced recovery after surgery reviewed and assessed the literature for quality and developed recommendations for each topic based on the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. All recommendations were graded following a consensus discussion among the expert panel. FINDINGS: The literature search, including a hand search of reference lists, identified 215 relevant publications that were considered to be the best evidence for the topic areas. A total of 17 topic areas were identified for inclusion in the protocol for the perioperative care of patients undergoing major head and neck cancer surgery with free flap reconstruction. Best practice includes several elements of perioperative care. Among these elements are the provision of preoperative carbohydrate treatment, pharmacologic thromboprophylaxis, perioperative antibiotics in clean-contaminated procedures, corticosteroid and antiemetic medications, short acting anxiolytics, goal-directed fluid management, opioid-sparing multimodal analgesia, frequent flap monitoring, early mobilization, and the avoidance of preoperative fasting. CONCLUSIONS AND RELEVANCE: The evidence base for specific perioperative care elements in head and neck cancer surgery is variable and in many cases information from different surgerical procedures form the basis for these recommendations. Clinical evaluation of these recommendations is a logical next step and further research in this patient population is warranted.

Original languageEnglish (US)
Pages (from-to)292-303
Number of pages12
JournalJAMA Otolaryngology - Head and Neck Surgery
Volume143
Issue number3
DOIs
StatePublished - Mar 1 2017

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Perioperative Care
Free Tissue Flaps
Head and Neck Neoplasms
Publications
Pharyngectomy
Neck
Randomized Controlled Trials
Glossectomy
Head
Population
Early Ambulation
Laryngectomy
Neck Dissection
Antiemetics
Anti-Anxiety Agents
Thyroidectomy
Lymph Node Excision
Practice Guidelines
PubMed
Analgesia

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction : A consensus review and recommendations from the enhanced recovery after surgery society. / Dort, Joseph C.; Farwell, D Gregory; Findlay, Merran; Huber, Gerhard F.; Kerr, Paul; Shea-Budgell, Melissa A.; Simon, Christian; Uppington, Jeffrey; Zygun, David; Ljungqvist, Olle; Harris, Jeffrey.

In: JAMA Otolaryngology - Head and Neck Surgery, Vol. 143, No. 3, 01.03.2017, p. 292-303.

Research output: Contribution to journalReview article

Dort, Joseph C. ; Farwell, D Gregory ; Findlay, Merran ; Huber, Gerhard F. ; Kerr, Paul ; Shea-Budgell, Melissa A. ; Simon, Christian ; Uppington, Jeffrey ; Zygun, David ; Ljungqvist, Olle ; Harris, Jeffrey. / Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction : A consensus review and recommendations from the enhanced recovery after surgery society. In: JAMA Otolaryngology - Head and Neck Surgery. 2017 ; Vol. 143, No. 3. pp. 292-303.
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AU - Kerr, Paul

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N2 - IMPORTANCE: Head and neck cancers often require complex, labor-intensive surgeries, especially when free flap reconstruction is required. Enhanced recovery is important in this patient population but evidence-based protocols on perioperative care for this population are lacking. OBJECTIVE: To provide a consensus-based protocol for optimal perioperative care of patients undergoing head and neck cancer surgery with free flap reconstruction. EVIDENCE REVIEW: Following endorsement by the Enhanced Recovery After Surgery (ERAS) Society to develop this protocol, a systematic review was conducted for each topic. The PubMed and Cochrane databases were initially searched to identify relevant publications on head and neck cancer surgery from 1965 through April 2015. Consistent key words for each topic included "head and neck surgery," "pharyngectomy," "laryngectomy," "laryngopharyngectomy," "neck dissection,""parotid lymphadenectomy,""thyroidectomy,""oral cavity resection,""glossectomy," and "head and neck." The final selection of literature included meta-analyses and systematic reviews as well as randomized controlled trials where available. In the absence of high-level data, case series and nonrandomized studies in head and neck cancer surgery patients or randomized controlled trials and systematic reviews in non-head and neck cancer surgery patients, were considered. An international panel of experts in major head and neck cancer surgery and enhanced recovery after surgery reviewed and assessed the literature for quality and developed recommendations for each topic based on the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. All recommendations were graded following a consensus discussion among the expert panel. FINDINGS: The literature search, including a hand search of reference lists, identified 215 relevant publications that were considered to be the best evidence for the topic areas. A total of 17 topic areas were identified for inclusion in the protocol for the perioperative care of patients undergoing major head and neck cancer surgery with free flap reconstruction. Best practice includes several elements of perioperative care. Among these elements are the provision of preoperative carbohydrate treatment, pharmacologic thromboprophylaxis, perioperative antibiotics in clean-contaminated procedures, corticosteroid and antiemetic medications, short acting anxiolytics, goal-directed fluid management, opioid-sparing multimodal analgesia, frequent flap monitoring, early mobilization, and the avoidance of preoperative fasting. CONCLUSIONS AND RELEVANCE: The evidence base for specific perioperative care elements in head and neck cancer surgery is variable and in many cases information from different surgerical procedures form the basis for these recommendations. Clinical evaluation of these recommendations is a logical next step and further research in this patient population is warranted.

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