Optimal medetomidine dose when combined with ketamine and tiletamine-zolazepam to immobilize white-tailed deer

Lisa I. Muller, David A. Osborn, Tom Doherty, Michael K Keel, Brad F. Miller, Robert J. Warren, Karl V. Miller

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Chemical immobilization is often needed for safe and effective capture and handling of wildlife. We evaluated medetomidine (125, 150, 175, or 200 μg/kg; for synergistic effects and relaxation) mixed with ketamine (1.5 mg/kg; for relatively shorter recovery) and tiletamine-zolazepam (1.0 mg/kg; for rapid induction) in 22 female white-tailed deer (Odocoileus virginianus) at the University of Georgia Whitehall Deer Research Facility in Athens, Georgia, USA, on 14-15 and 21 May 2009. Deer were weighed before treatment, hand-injected intramuscularly (IM) while restrained in a squeeze chute, and released into a pen for monitoring. We measured rectal temperature, respiration rate, heart rate, hemoglobin saturation (using pulse oximetry), and arterial blood gases at 0, 10, and 20 min postimmobilization. We found no differences in induction time with different doses of medetomidine. Deer became laterally recumbent for all treatments combined at a median of 4.2 (2.6-21.3) min and were approachable by a median of 4.8 (3.5-21.8) min. Twelve of the 22 deer had rectal temperatures >40 C at time 0 and were treated with a cold-water enema. Hemoglobin saturation, estimated using pulse oximetry, was 79.5, 82.0, and 82.3% at times 0, 10, and 20, respectively. We injected atipamezole (0.35 mg/kg, IM) for reversal. Recovery occurred sooner and was more consistent for 125 and 150 μg/kg medetomidine whereby deer stood with minimal sedation to moderate ataxia within 60-90 min after atipamezole administration. We recommend using 150 mg of medetomidine with ketamine (1.5 mg/kg) and tiletamine-zolazepam (1.0 mg/kg) to provide effective and safe chemical immobilization of white-tailed deer.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalJournal of Wildlife Diseases
Volume48
Issue number2
StatePublished - 2012
Externally publishedYes

Fingerprint

tiletamine
medetomidine
ketamine
Odocoileus virginianus
deer
dosage
hemoglobin
chutes
immobilization
research facilities
blood gases
sedation
saturation
heart rate
wildlife
temperature
hands
dose
cold water
monitoring

Keywords

  • Arterial blood gases
  • Chemical immobilization
  • Ketamine
  • Medetomidine
  • Odocoileus virginianus
  • Telazol
  • Tiletaminezolazepam
  • White-tailed deer

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

Muller, L. I., Osborn, D. A., Doherty, T., Keel, M. K., Miller, B. F., Warren, R. J., & Miller, K. V. (2012). Optimal medetomidine dose when combined with ketamine and tiletamine-zolazepam to immobilize white-tailed deer. Journal of Wildlife Diseases, 48(2), 477-482.

Optimal medetomidine dose when combined with ketamine and tiletamine-zolazepam to immobilize white-tailed deer. / Muller, Lisa I.; Osborn, David A.; Doherty, Tom; Keel, Michael K; Miller, Brad F.; Warren, Robert J.; Miller, Karl V.

In: Journal of Wildlife Diseases, Vol. 48, No. 2, 2012, p. 477-482.

Research output: Contribution to journalArticle

Muller, LI, Osborn, DA, Doherty, T, Keel, MK, Miller, BF, Warren, RJ & Miller, KV 2012, 'Optimal medetomidine dose when combined with ketamine and tiletamine-zolazepam to immobilize white-tailed deer', Journal of Wildlife Diseases, vol. 48, no. 2, pp. 477-482.
Muller, Lisa I. ; Osborn, David A. ; Doherty, Tom ; Keel, Michael K ; Miller, Brad F. ; Warren, Robert J. ; Miller, Karl V. / Optimal medetomidine dose when combined with ketamine and tiletamine-zolazepam to immobilize white-tailed deer. In: Journal of Wildlife Diseases. 2012 ; Vol. 48, No. 2. pp. 477-482.
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