Optimal Duration of Continuous Video-Electroencephalography in Term Infants with Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia

Naeem Mahfooz, Arie Weinstock, Bushra Afzal, Mariam Noor, David Vargas Lowy, Osman Farooq, Sarah G. Finnegan, Satyanarayana Lakshminrusimha

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Continuous video-electroencephalography (EEG) is an important diagnostic and prognostic tool in newborns with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. The optimal duration of continuous video-EEG during whole-body hypothermia is not known. We conducted a retrospective study of 35 neonates with hypoxic-ischemic encephalopathy undergoing whole-body hypothermia with continuous video-EEG. EEG ictal changes were detected in 9/35 infants (26%). Of these 9 infants, the seizures were initially observed within 30 minutes of EEG monitoring in 6 (67%), within 24 hours in 2 (22%), and during rewarming in 1 infant (11%). No new seizures were detected between 24-72 hours of therapeutic hypothermia. Background suppression was detected in 14 infants (40%) by 24 hours. In neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia, continuous video-EEG has the highest diagnostic yield within the first 24 hours and during the rewarming phase. In the absence of prior seizures or antiepileptic therapy, limiting continuous video-EEG to these periods in resource-limited settings may reduce cost during therapeutic hypothermia.

Original languageEnglish (US)
Pages (from-to)522-527
Number of pages6
JournalJournal of Child Neurology
Volume32
Issue number6
DOIs
StatePublished - May 1 2017
Externally publishedYes

Fingerprint

Brain Hypoxia-Ischemia
Induced Hypothermia
Electroencephalography
Rewarming
Newborn Infant
Hypothermia
Seizures
Absence Epilepsy
Anticonvulsants
Retrospective Studies
Stroke
Costs and Cost Analysis

Keywords

  • background suppression
  • cooling
  • electroencephalography
  • hypoxic ischemic encephalopathy
  • seizures
  • whole body hypothermia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Optimal Duration of Continuous Video-Electroencephalography in Term Infants with Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia. / Mahfooz, Naeem; Weinstock, Arie; Afzal, Bushra; Noor, Mariam; Lowy, David Vargas; Farooq, Osman; Finnegan, Sarah G.; Lakshminrusimha, Satyanarayana.

In: Journal of Child Neurology, Vol. 32, No. 6, 01.05.2017, p. 522-527.

Research output: Contribution to journalArticle

Mahfooz, Naeem ; Weinstock, Arie ; Afzal, Bushra ; Noor, Mariam ; Lowy, David Vargas ; Farooq, Osman ; Finnegan, Sarah G. ; Lakshminrusimha, Satyanarayana. / Optimal Duration of Continuous Video-Electroencephalography in Term Infants with Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia. In: Journal of Child Neurology. 2017 ; Vol. 32, No. 6. pp. 522-527.
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