Optimal Duration of Continuous Video-Electroencephalography in Term Infants with Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia

Naeem Mahfooz, Arie Weinstock, Bushra Afzal, Mariam Noor, David Vargas Lowy, Osman Farooq, Sarah G. Finnegan, Satyanarayana Lakshminrusimha

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Continuous video-electroencephalography (EEG) is an important diagnostic and prognostic tool in newborns with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. The optimal duration of continuous video-EEG during whole-body hypothermia is not known. We conducted a retrospective study of 35 neonates with hypoxic-ischemic encephalopathy undergoing whole-body hypothermia with continuous video-EEG. EEG ictal changes were detected in 9/35 infants (26%). Of these 9 infants, the seizures were initially observed within 30 minutes of EEG monitoring in 6 (67%), within 24 hours in 2 (22%), and during rewarming in 1 infant (11%). No new seizures were detected between 24-72 hours of therapeutic hypothermia. Background suppression was detected in 14 infants (40%) by 24 hours. In neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia, continuous video-EEG has the highest diagnostic yield within the first 24 hours and during the rewarming phase. In the absence of prior seizures or antiepileptic therapy, limiting continuous video-EEG to these periods in resource-limited settings may reduce cost during therapeutic hypothermia.

Original languageEnglish (US)
Pages (from-to)522-527
Number of pages6
JournalJournal of Child Neurology
Volume32
Issue number6
DOIs
StatePublished - May 1 2017
Externally publishedYes

Keywords

  • background suppression
  • cooling
  • electroencephalography
  • hypoxic ischemic encephalopathy
  • seizures
  • whole body hypothermia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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