Optimal design of feedback control by inhibition - steady state considerations

Michael A. Savageau

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


A recently developed, nonlinear method of systems analysis has been used to compare alternative patterns of control by feedback inhibition in otherwise equivalent unbranched biosynthetic pathways. The steady state performance of the simple case with end-product inhibition at the first physiologically important step is optimal with respect to the following criteria: the ability to (i) meet an increased demand for the end-product, (ii) meet this increased demand with limited accumulation of the intermediates, (iii) respond to an increased supply of the initial substrate, and (iv) limit the accumulation of the intermediates while responding to the increased availability of the initial substrate. The importance of these properties for the selection of feedback patterns in biosynthetic pathways is discussed.

Original languageEnglish (US)
Pages (from-to)139-156
Number of pages18
JournalJournal of Molecular Evolution
Issue number2
StatePublished - Jun 1974
Externally publishedYes


  • Biosynthetic Pathways
  • Control Patterns
  • Natural Selection

ASJC Scopus subject areas

  • Genetics(clinical)
  • Molecular Biology
  • Genetics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)


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